Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones

Detalhes bibliográficos
Autor(a) principal: Kyungjin,Kim
Data de Publicação: 1998
Outros Autores: Volkman,Steven K., Ellman,Jonathan A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531998000400010
Resumo: The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (SLE).
id SBQ-2_ddbab9588e627ba1a0d1362a4144b580
oai_identifier_str oai:scielo:S0103-50531998000400010
network_acronym_str SBQ-2
network_name_str Journal of the Brazilian Chemical Society (Online)
repository_id_str
spelling Synthesis of 3-Substituted 1,4-Benzodiazepin-2-onesbenzodiazepine enolate-alkylationsystemic lupus erythematosusThe preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (SLE).Sociedade Brasileira de Química1998-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531998000400010Journal of the Brazilian Chemical Society v.9 n.4 1998reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50531998000400010info:eu-repo/semantics/openAccessKyungjin,KimVolkman,Steven K.Ellman,Jonathan A.eng2002-10-30T00:00:00Zoai:scielo:S0103-50531998000400010Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2002-10-30T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
title Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
spellingShingle Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
Kyungjin,Kim
benzodiazepine enolate-alkylation
systemic lupus erythematosus
title_short Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
title_full Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
title_fullStr Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
title_full_unstemmed Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
title_sort Synthesis of 3-Substituted 1,4-Benzodiazepin-2-ones
author Kyungjin,Kim
author_facet Kyungjin,Kim
Volkman,Steven K.
Ellman,Jonathan A.
author_role author
author2 Volkman,Steven K.
Ellman,Jonathan A.
author2_role author
author
dc.contributor.author.fl_str_mv Kyungjin,Kim
Volkman,Steven K.
Ellman,Jonathan A.
dc.subject.por.fl_str_mv benzodiazepine enolate-alkylation
systemic lupus erythematosus
topic benzodiazepine enolate-alkylation
systemic lupus erythematosus
description The preparation of 3-substituted 1,4-benzodiazepines by benzodiazepine enolate alkylation has been explored. Employing this approach, multigram quantities of benzodiazepine 1 have been prepared for animal studies to evaluate a new approach for the treatment of the autoimmune disease systemic lupus erythematosus (SLE).
publishDate 1998
dc.date.none.fl_str_mv 1998-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531998000400010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531998000400010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50531998000400010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.9 n.4 1998
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
_version_ 1750318163418939392

Registros relacionados