Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines

Detalhes bibliográficos
Autor(a) principal: Rohini,Rondla
Data de Publicação: 2010
Outros Autores: Shanker,Kanne, Reddy,P. Muralidhar, Ravinder,Vadde
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100009
Resumo: A series of 6-arylbenzimidazo[1,2-c]quinazoline compounds (11-20) were synthesised by the condensation of 2-(o-aminophenyl)benzimidazole with different arylaldehydes, followed by oxidative cyclisation of the resulting 2-o-arylideneaminophenylbenzimidazoles (1-10). All the products were characterized via IR, ¹H NMR, 13C NMR, MS and elemental analysis. The antimicrobial activities of all 6-arylbenzimidazo [1,2-c]quinazolines against three Gram-positive (S. aureus, B. subtilis, S. pyogenes), three Gram-negative (S. typhimurium, E. coli, K. pneumonia) bacteria and three fungal strains (A. niger, C. albicans, T. viridae) were evaluated. Among the compounds tested 13, 19 and 20 showed most potent inhibitory action against test organisms.
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spelling Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines6-Arylbenzimidazo[1,2-c]quinazolinessynthesisantibacterial activityantifungal activityA series of 6-arylbenzimidazo[1,2-c]quinazoline compounds (11-20) were synthesised by the condensation of 2-(o-aminophenyl)benzimidazole with different arylaldehydes, followed by oxidative cyclisation of the resulting 2-o-arylideneaminophenylbenzimidazoles (1-10). All the products were characterized via IR, ¹H NMR, 13C NMR, MS and elemental analysis. The antimicrobial activities of all 6-arylbenzimidazo [1,2-c]quinazolines against three Gram-positive (S. aureus, B. subtilis, S. pyogenes), three Gram-negative (S. typhimurium, E. coli, K. pneumonia) bacteria and three fungal strains (A. niger, C. albicans, T. viridae) were evaluated. Among the compounds tested 13, 19 and 20 showed most potent inhibitory action against test organisms.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100009Journal of the Brazilian Chemical Society v.21 n.1 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000100009info:eu-repo/semantics/openAccessRohini,RondlaShanker,KanneReddy,P. MuralidharRavinder,Vaddeeng2010-02-18T00:00:00Zoai:scielo:S0103-50532010000100009Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-02-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
title Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
spellingShingle Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
Rohini,Rondla
6-Arylbenzimidazo[1,2-c]quinazolines
synthesis
antibacterial activity
antifungal activity
title_short Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
title_full Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
title_fullStr Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
title_full_unstemmed Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
title_sort Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
author Rohini,Rondla
author_facet Rohini,Rondla
Shanker,Kanne
Reddy,P. Muralidhar
Ravinder,Vadde
author_role author
author2 Shanker,Kanne
Reddy,P. Muralidhar
Ravinder,Vadde
author2_role author
author
author
dc.contributor.author.fl_str_mv Rohini,Rondla
Shanker,Kanne
Reddy,P. Muralidhar
Ravinder,Vadde
dc.subject.por.fl_str_mv 6-Arylbenzimidazo[1,2-c]quinazolines
synthesis
antibacterial activity
antifungal activity
topic 6-Arylbenzimidazo[1,2-c]quinazolines
synthesis
antibacterial activity
antifungal activity
description A series of 6-arylbenzimidazo[1,2-c]quinazoline compounds (11-20) were synthesised by the condensation of 2-(o-aminophenyl)benzimidazole with different arylaldehydes, followed by oxidative cyclisation of the resulting 2-o-arylideneaminophenylbenzimidazoles (1-10). All the products were characterized via IR, ¹H NMR, 13C NMR, MS and elemental analysis. The antimicrobial activities of all 6-arylbenzimidazo [1,2-c]quinazolines against three Gram-positive (S. aureus, B. subtilis, S. pyogenes), three Gram-negative (S. typhimurium, E. coli, K. pneumonia) bacteria and three fungal strains (A. niger, C. albicans, T. viridae) were evaluated. Among the compounds tested 13, 19 and 20 showed most potent inhibitory action against test organisms.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532010000100009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.1 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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