Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000501157 |
Resumo: | The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum's acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin. |
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Journal of the Brazilian Chemical Society (Online) |
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Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activatornatural productsepigeneticssirtuinscoumarinsThe total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum's acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.Sociedade Brasileira de Química2018-05-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000501157Journal of the Brazilian Chemical Society v.29 n.5 2018reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20180021info:eu-repo/semantics/openAccessSilva,Anna C.Benelkebir,HanaeLopes,Rosangela S. C.Lopes,Claudio C.Ganesan,A.eng2018-07-04T00:00:00Zoai:scielo:S0103-50532018000501157Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2018-07-04T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
title |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
spellingShingle |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator Silva,Anna C. natural products epigenetics sirtuins coumarins |
title_short |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
title_full |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
title_fullStr |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
title_full_unstemmed |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
title_sort |
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator |
author |
Silva,Anna C. |
author_facet |
Silva,Anna C. Benelkebir,Hanae Lopes,Rosangela S. C. Lopes,Claudio C. Ganesan,A. |
author_role |
author |
author2 |
Benelkebir,Hanae Lopes,Rosangela S. C. Lopes,Claudio C. Ganesan,A. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva,Anna C. Benelkebir,Hanae Lopes,Rosangela S. C. Lopes,Claudio C. Ganesan,A. |
dc.subject.por.fl_str_mv |
natural products epigenetics sirtuins coumarins |
topic |
natural products epigenetics sirtuins coumarins |
description |
The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum's acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000501157 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000501157 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20180021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.29 n.5 2018 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318180793843712 |