Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318

Detalhes bibliográficos
Autor(a) principal: Yao,Guangmin
Data de Publicação: 2011
Outros Autores: Sebisubi,Fred Musoke, Voo,Lok Yung Christopher, Ho,Coy Choke, Tan,Ghee Teng, Chang,Leng Chee
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600018
Resumo: Investigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone (1), along with four known citrinin derivatives (2-5). Citrinin (2) exhibited significant inhibitory activity against Streptomyces 85E in the hyphae formation inhibition (HFI) assay, while compounds 1, 3-5 were not active when tested at 20 mg/disk in the HFI assay. Citrinin (2) further demonstrated a weak inhibitory activity against MCF-7 (IC50 71.93 µmol L-1), LNCaP (IC50 77.92 µmol L-1), LU-1 (147.85 µmol L-1) and KB (IC50 65.93 µmol L-1) cell lines, respectively, in the cytotoxicity assay.
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spelling Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318Streptomyces 85Eisoquinolinone alkaloidcitrininPenicillium sp. H9318kinase inhibitorInvestigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone (1), along with four known citrinin derivatives (2-5). Citrinin (2) exhibited significant inhibitory activity against Streptomyces 85E in the hyphae formation inhibition (HFI) assay, while compounds 1, 3-5 were not active when tested at 20 mg/disk in the HFI assay. Citrinin (2) further demonstrated a weak inhibitory activity against MCF-7 (IC50 71.93 µmol L-1), LNCaP (IC50 77.92 µmol L-1), LU-1 (147.85 µmol L-1) and KB (IC50 65.93 µmol L-1) cell lines, respectively, in the cytotoxicity assay.Sociedade Brasileira de Química2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600018Journal of the Brazilian Chemical Society v.22 n.6 2011reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532011000600018info:eu-repo/semantics/openAccessYao,GuangminSebisubi,Fred MusokeVoo,Lok Yung ChristopherHo,Coy ChokeTan,Ghee TengChang,Leng Cheeeng2011-06-10T00:00:00Zoai:scielo:S0103-50532011000600018Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2011-06-10T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
title Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
spellingShingle Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
Yao,Guangmin
Streptomyces 85E
isoquinolinone alkaloid
citrinin
Penicillium sp. H9318
kinase inhibitor
title_short Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
title_full Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
title_fullStr Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
title_full_unstemmed Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
title_sort Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318
author Yao,Guangmin
author_facet Yao,Guangmin
Sebisubi,Fred Musoke
Voo,Lok Yung Christopher
Ho,Coy Choke
Tan,Ghee Teng
Chang,Leng Chee
author_role author
author2 Sebisubi,Fred Musoke
Voo,Lok Yung Christopher
Ho,Coy Choke
Tan,Ghee Teng
Chang,Leng Chee
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Yao,Guangmin
Sebisubi,Fred Musoke
Voo,Lok Yung Christopher
Ho,Coy Choke
Tan,Ghee Teng
Chang,Leng Chee
dc.subject.por.fl_str_mv Streptomyces 85E
isoquinolinone alkaloid
citrinin
Penicillium sp. H9318
kinase inhibitor
topic Streptomyces 85E
isoquinolinone alkaloid
citrinin
Penicillium sp. H9318
kinase inhibitor
description Investigation of a microbial fermentation organic extract of Penicillium sp. H9318 led to the isolation of a new isoquinolinone alkaloid, (5S)-3,4,5,7-tetramethyl-5,8-dihydroxyl-6(5H)-isoquinolinone (1), along with four known citrinin derivatives (2-5). Citrinin (2) exhibited significant inhibitory activity against Streptomyces 85E in the hyphae formation inhibition (HFI) assay, while compounds 1, 3-5 were not active when tested at 20 mg/disk in the HFI assay. Citrinin (2) further demonstrated a weak inhibitory activity against MCF-7 (IC50 71.93 µmol L-1), LNCaP (IC50 77.92 µmol L-1), LU-1 (147.85 µmol L-1) and KB (IC50 65.93 µmol L-1) cell lines, respectively, in the cytotoxicity assay.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532011000600018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532011000600018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.22 n.6 2011
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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