Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes

Detalhes bibliográficos
Autor(a) principal: Heli,H.
Data de Publicação: 2010
Outros Autores: Faramarzi,F., Jabbari,A., Parsaei,A., Moosavi-Movahedi,A. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004
Resumo: The electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×10³ cm³ mol-1 s-1 and 1.55×10-6 cm² s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values.
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spelling Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodesetidronatebisphosphonate drugcoppernanoparticleelectrocatalysismodified electrodeThe electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×10³ cm³ mol-1 s-1 and 1.55×10-6 cm² s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004Journal of the Brazilian Chemical Society v.21 n.1 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000100004info:eu-repo/semantics/openAccessHeli,H.Faramarzi,F.Jabbari,A.Parsaei,A.Moosavi-Movahedi,A. A.eng2010-02-19T00:00:00Zoai:scielo:S0103-50532010000100004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-02-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
title Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
spellingShingle Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
Heli,H.
etidronate
bisphosphonate drug
copper
nanoparticle
electrocatalysis
modified electrode
title_short Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
title_full Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
title_fullStr Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
title_full_unstemmed Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
title_sort Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
author Heli,H.
author_facet Heli,H.
Faramarzi,F.
Jabbari,A.
Parsaei,A.
Moosavi-Movahedi,A. A.
author_role author
author2 Faramarzi,F.
Jabbari,A.
Parsaei,A.
Moosavi-Movahedi,A. A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Heli,H.
Faramarzi,F.
Jabbari,A.
Parsaei,A.
Moosavi-Movahedi,A. A.
dc.subject.por.fl_str_mv etidronate
bisphosphonate drug
copper
nanoparticle
electrocatalysis
modified electrode
topic etidronate
bisphosphonate drug
copper
nanoparticle
electrocatalysis
modified electrode
description The electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×10³ cm³ mol-1 s-1 and 1.55×10-6 cm² s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0103-50532010000100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.21 n.1 2010
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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