Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004 |
Resumo: | The electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×10³ cm³ mol-1 s-1 and 1.55×10-6 cm² s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values. |
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Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodesetidronatebisphosphonate drugcoppernanoparticleelectrocatalysismodified electrodeThe electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×10³ cm³ mol-1 s-1 and 1.55×10-6 cm² s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004Journal of the Brazilian Chemical Society v.21 n.1 2010reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532010000100004info:eu-repo/semantics/openAccessHeli,H.Faramarzi,F.Jabbari,A.Parsaei,A.Moosavi-Movahedi,A. A.eng2010-02-19T00:00:00Zoai:scielo:S0103-50532010000100004Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2010-02-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
title |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
spellingShingle |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes Heli,H. etidronate bisphosphonate drug copper nanoparticle electrocatalysis modified electrode |
title_short |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
title_full |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
title_fullStr |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
title_full_unstemmed |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
title_sort |
Electrooxidation and determination of etidronate using copper nanoparticles and microparticles-modified carbon paste electrodes |
author |
Heli,H. |
author_facet |
Heli,H. Faramarzi,F. Jabbari,A. Parsaei,A. Moosavi-Movahedi,A. A. |
author_role |
author |
author2 |
Faramarzi,F. Jabbari,A. Parsaei,A. Moosavi-Movahedi,A. A. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Heli,H. Faramarzi,F. Jabbari,A. Parsaei,A. Moosavi-Movahedi,A. A. |
dc.subject.por.fl_str_mv |
etidronate bisphosphonate drug copper nanoparticle electrocatalysis modified electrode |
topic |
etidronate bisphosphonate drug copper nanoparticle electrocatalysis modified electrode |
description |
The electrochemical behavior and determination of a bisphosphonate drug, sodium etidronate, on three different copper-based electrodes: polycrystalline copper electrode (CE) and copper microparticles- (m-CPE) and copper nanoparticles (n-CPE)-modified carbon paste electrodes was investigated. In the voltammograms recorded using CE, one anodic peak was appeared while, both m-CPE and n-CPE represented two anodic oxidation peaks. The anodic current density at 610 mV for n-CPE is >5 times higher that of m-CPE. This was related to the nanosize effect of copper nanoparticles. The anodic currents were related to the electrocatalytic oxidation of etidronate via the electrogenerated active species of Cu(III) in an EC' mechanism. The catalytic rate constant for the oxidation process and the diffusion coefficient of etidronate were obtained as 8.9×10³ cm³ mol-1 s-1 and 1.55×10-6 cm² s-1, respectively. A sensitive and time-saving sensing procedure was developed for the analysis of etidronate, and the corresponding analytical parameters were reported. Etidronate was determined with a limit of detection of 10.57 μmol L-1 with a linear range of 200-2538 μmol L-1. Accuracy was also checked by recovery test on spiked samples. The proposed amperometric method was applied to the analysis of commercial pharmaceutical tablets and the results were in good agreement with the declared values. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532010000100004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-50532010000100004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.21 n.1 2010 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318170584907776 |