Microwave assisted synthesis of 6-Substituted aminopurine analogs in water

Detalhes bibliográficos
Autor(a) principal: Qu,Guirong
Data de Publicação: 2006
Outros Autores: Han,Suhui, Zhang,Zhiguang, Geng,Mingwei, Xue,Feng
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500015
Resumo: Microwave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.
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spelling Microwave assisted synthesis of 6-Substituted aminopurine analogs in wateramination6-substituted aminopurine analogsnucleophilic substitutionmicrowave irradiationaminesMicrowave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.Sociedade Brasileira de Química2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500015Journal of the Brazilian Chemical Society v.17 n.5 2006reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532006000500015info:eu-repo/semantics/openAccessQu,GuirongHan,SuhuiZhang,ZhiguangGeng,MingweiXue,Fengeng2006-12-01T00:00:00Zoai:scielo:S0103-50532006000500015Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2006-12-01T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
title Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
spellingShingle Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
Qu,Guirong
amination
6-substituted aminopurine analogs
nucleophilic substitution
microwave irradiation
amines
title_short Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
title_full Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
title_fullStr Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
title_full_unstemmed Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
title_sort Microwave assisted synthesis of 6-Substituted aminopurine analogs in water
author Qu,Guirong
author_facet Qu,Guirong
Han,Suhui
Zhang,Zhiguang
Geng,Mingwei
Xue,Feng
author_role author
author2 Han,Suhui
Zhang,Zhiguang
Geng,Mingwei
Xue,Feng
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Qu,Guirong
Han,Suhui
Zhang,Zhiguang
Geng,Mingwei
Xue,Feng
dc.subject.por.fl_str_mv amination
6-substituted aminopurine analogs
nucleophilic substitution
microwave irradiation
amines
topic amination
6-substituted aminopurine analogs
nucleophilic substitution
microwave irradiation
amines
description Microwave assisted amination of 6-chloropurine derivatives with various amines in water resulted in a "green chemistry" protocol for the preparation of 6-substituted aminopurine analogs in very good yields. Using a simply modified microwave oven with the refluxing apparatus, the amination of the 6-chloro in the purine structure occurred smoothly. 19 known and 16 unknown 6-substituted aminopurine analogs were prepared through nucleophilic aromatic substitution with simple filtration or column chromatography.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532006000500015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532006000500015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.17 n.5 2006
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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