Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)

Detalhes bibliográficos
Autor(a) principal: Sant Ana Filho,Carlos R.
Data de Publicação: 2013
Outros Autores: Tavares,Claudinéia R. O., Ferreira,André V., Prestes,Clelber V., Bendassolli,José A.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100020
Resumo: The aim of the study was to synthesize the urea (13CO(NH2)2), with 99% 13C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine.
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spelling Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)stable isotopereactorenriched compoundsThe aim of the study was to synthesize the urea (13CO(NH2)2), with 99% 13C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine.Sociedade Brasileira de Química2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100020Química Nova v.36 n.1 2013reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422013000100020info:eu-repo/semantics/openAccessSant Ana Filho,Carlos R.Tavares,Claudinéia R. O.Ferreira,André V.Prestes,Clelber V.Bendassolli,José A.por2013-02-15T00:00:00Zoai:scielo:S0100-40422013000100020Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2013-02-15T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
title Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
spellingShingle Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
Sant Ana Filho,Carlos R.
stable isotope
reactor
enriched compounds
title_short Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
title_full Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
title_fullStr Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
title_full_unstemmed Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
title_sort Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)
author Sant Ana Filho,Carlos R.
author_facet Sant Ana Filho,Carlos R.
Tavares,Claudinéia R. O.
Ferreira,André V.
Prestes,Clelber V.
Bendassolli,José A.
author_role author
author2 Tavares,Claudinéia R. O.
Ferreira,André V.
Prestes,Clelber V.
Bendassolli,José A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sant Ana Filho,Carlos R.
Tavares,Claudinéia R. O.
Ferreira,André V.
Prestes,Clelber V.
Bendassolli,José A.
dc.subject.por.fl_str_mv stable isotope
reactor
enriched compounds
topic stable isotope
reactor
enriched compounds
description The aim of the study was to synthesize the urea (13CO(NH2)2), with 99% 13C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100020
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422013000100020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.36 n.1 2013
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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