Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma

Detalhes bibliográficos
Autor(a) principal: Porto,Carlos Eduardo Dobrovolskni
Data de Publicação: 2012
Outros Autores: Maia,Patrícia Penido, Freitas,Daniela Fernanda de, Araújo,Rafhaella Carolina Cedro, Siqueira,Maria Elisa Pereira Bastos de, Martins,Isarita, Santos-Neto,Álvaro José dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100014
Resumo: A method using Liquid Phase Microextraction for simultaneous detection of citalopram (CIT), paroxetine (PAR) and fluoxetine (FLU), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. The linearity was evaluated between 5.0 and 500 ng mL-1 (r > 0.99) and the limit of quantification was 2.0, 3.0 and 5.0 ng mL-1 for CIT, PAR and FLU, respectively. Therefore, it can be applied to therapeutic drug monitoring, pharmacokinetics or bioavailability studies and its advantages are that it necessary relatively inexpensive equipment and sample preparation techniques.
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spelling Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasmaLPMEantidepressantsHPLC-FLA method using Liquid Phase Microextraction for simultaneous detection of citalopram (CIT), paroxetine (PAR) and fluoxetine (FLU), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. The linearity was evaluated between 5.0 and 500 ng mL-1 (r > 0.99) and the limit of quantification was 2.0, 3.0 and 5.0 ng mL-1 for CIT, PAR and FLU, respectively. Therefore, it can be applied to therapeutic drug monitoring, pharmacokinetics or bioavailability studies and its advantages are that it necessary relatively inexpensive equipment and sample preparation techniques.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100014Química Nova v.35 n.1 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000100014info:eu-repo/semantics/openAccessPorto,Carlos Eduardo DobrovolskniMaia,Patrícia PenidoFreitas,Daniela Fernanda deAraújo,Rafhaella Carolina CedroSiqueira,Maria Elisa Pereira Bastos deMartins,IsaritaSantos-Neto,Álvaro José doseng2012-02-27T00:00:00Zoai:scielo:S0100-40422012000100014Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-02-27T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
title Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
spellingShingle Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
Porto,Carlos Eduardo Dobrovolskni
LPME
antidepressants
HPLC-FL
title_short Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
title_full Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
title_fullStr Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
title_full_unstemmed Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
title_sort Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma
author Porto,Carlos Eduardo Dobrovolskni
author_facet Porto,Carlos Eduardo Dobrovolskni
Maia,Patrícia Penido
Freitas,Daniela Fernanda de
Araújo,Rafhaella Carolina Cedro
Siqueira,Maria Elisa Pereira Bastos de
Martins,Isarita
Santos-Neto,Álvaro José dos
author_role author
author2 Maia,Patrícia Penido
Freitas,Daniela Fernanda de
Araújo,Rafhaella Carolina Cedro
Siqueira,Maria Elisa Pereira Bastos de
Martins,Isarita
Santos-Neto,Álvaro José dos
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Porto,Carlos Eduardo Dobrovolskni
Maia,Patrícia Penido
Freitas,Daniela Fernanda de
Araújo,Rafhaella Carolina Cedro
Siqueira,Maria Elisa Pereira Bastos de
Martins,Isarita
Santos-Neto,Álvaro José dos
dc.subject.por.fl_str_mv LPME
antidepressants
HPLC-FL
topic LPME
antidepressants
HPLC-FL
description A method using Liquid Phase Microextraction for simultaneous detection of citalopram (CIT), paroxetine (PAR) and fluoxetine (FLU), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. The linearity was evaluated between 5.0 and 500 ng mL-1 (r > 0.99) and the limit of quantification was 2.0, 3.0 and 5.0 ng mL-1 for CIT, PAR and FLU, respectively. Therefore, it can be applied to therapeutic drug monitoring, pharmacokinetics or bioavailability studies and its advantages are that it necessary relatively inexpensive equipment and sample preparation techniques.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000100014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.1 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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