UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS

Detalhes bibliográficos
Autor(a) principal: Souza,Mariana Barbosa André de
Data de Publicação: 2017
Outros Autores: Fontana,Klaiani Bez, Gonçalves,Caroline, Chaves,Eduardo Sidinei
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017001001228
Resumo: The utilization of atomic absorption spectrometer for metformin (MET) and ranitidine (RAN) chlorohydrates determination in medicines is proposed. The spectral lines of nickel and aluminum at 232.0 and 308.2 nm were selected for MET and RAN absorbance monitoring, respectively. The results were compared to those obtained by molecular absorption spectrometry at ultraviolet range (spectrophotometry) and condutometric titration. The figures of merit obtained were adequate for MET and RAN determination in medicines. The limit of detection (LOD) of 0.01 mg L-1 obtained for MET and RAN, were similar and even lowers than those obtained by spectrophotometry and comparable with those found in the literature. The precision evaluated by relative standard deviation (RSD) was lower than 6%. The analytical application shows that in the analyzed samples the MET and RAN concentrations were in agreement with specified value in the label and the limits required by Brazilian legislation.
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spelling UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOSatomic absorption spectrometermolecular absorptionmetforminranitidinemedicinesThe utilization of atomic absorption spectrometer for metformin (MET) and ranitidine (RAN) chlorohydrates determination in medicines is proposed. The spectral lines of nickel and aluminum at 232.0 and 308.2 nm were selected for MET and RAN absorbance monitoring, respectively. The results were compared to those obtained by molecular absorption spectrometry at ultraviolet range (spectrophotometry) and condutometric titration. The figures of merit obtained were adequate for MET and RAN determination in medicines. The limit of detection (LOD) of 0.01 mg L-1 obtained for MET and RAN, were similar and even lowers than those obtained by spectrophotometry and comparable with those found in the literature. The precision evaluated by relative standard deviation (RSD) was lower than 6%. The analytical application shows that in the analyzed samples the MET and RAN concentrations were in agreement with specified value in the label and the limits required by Brazilian legislation.Sociedade Brasileira de Química2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017001001228Química Nova v.40 n.10 2017reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170121info:eu-repo/semantics/openAccessSouza,Mariana Barbosa André deFontana,Klaiani BezGonçalves,CarolineChaves,Eduardo Sidineipor2017-12-22T00:00:00Zoai:scielo:S0100-40422017001001228Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2017-12-22T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
title UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
spellingShingle UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
Souza,Mariana Barbosa André de
atomic absorption spectrometer
molecular absorption
metformin
ranitidine
medicines
title_short UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
title_full UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
title_fullStr UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
title_full_unstemmed UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
title_sort UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS
author Souza,Mariana Barbosa André de
author_facet Souza,Mariana Barbosa André de
Fontana,Klaiani Bez
Gonçalves,Caroline
Chaves,Eduardo Sidinei
author_role author
author2 Fontana,Klaiani Bez
Gonçalves,Caroline
Chaves,Eduardo Sidinei
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza,Mariana Barbosa André de
Fontana,Klaiani Bez
Gonçalves,Caroline
Chaves,Eduardo Sidinei
dc.subject.por.fl_str_mv atomic absorption spectrometer
molecular absorption
metformin
ranitidine
medicines
topic atomic absorption spectrometer
molecular absorption
metformin
ranitidine
medicines
description The utilization of atomic absorption spectrometer for metformin (MET) and ranitidine (RAN) chlorohydrates determination in medicines is proposed. The spectral lines of nickel and aluminum at 232.0 and 308.2 nm were selected for MET and RAN absorbance monitoring, respectively. The results were compared to those obtained by molecular absorption spectrometry at ultraviolet range (spectrophotometry) and condutometric titration. The figures of merit obtained were adequate for MET and RAN determination in medicines. The limit of detection (LOD) of 0.01 mg L-1 obtained for MET and RAN, were similar and even lowers than those obtained by spectrophotometry and comparable with those found in the literature. The precision evaluated by relative standard deviation (RSD) was lower than 6%. The analytical application shows that in the analyzed samples the MET and RAN concentrations were in agreement with specified value in the label and the limits required by Brazilian legislation.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017001001228
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422017001001228
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170121
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.40 n.10 2017
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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