LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS

Detalhes bibliográficos
Autor(a) principal: Duarte,Susyanne L. F.
Data de Publicação: 2018
Outros Autores: Nascimento,Yuri M., Madeiro,Sara A. L., Costa,Vicente C. O., Agra,Maria F., Sobral,Marianna V., Braz-Filho,Raimundo, Carvalho,Mario G., Carvalho,João E., Ruiz,Ana L. T. G., Turri,Larissa S., Silva,Marcelo S., Tavares,Josean F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018000800880
Resumo: The secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI50 values of 2.28, 3.29 and 5.76 mol L-1, respectively.
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spelling LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUSlignansPhyllanthuscytotoxicityglioma cellsThe secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI50 values of 2.28, 3.29 and 5.76 mol L-1, respectively.Sociedade Brasileira de Química2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018000800880Química Nova v.41 n.8 2018reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170266info:eu-repo/semantics/openAccessDuarte,Susyanne L. F.Nascimento,Yuri M.Madeiro,Sara A. L.Costa,Vicente C. O.Agra,Maria F.Sobral,Marianna V.Braz-Filho,RaimundoCarvalho,Mario G.Carvalho,João E.Ruiz,Ana L. T. G.Turri,Larissa S.Silva,Marcelo S.Tavares,Josean F.eng2018-10-16T00:00:00Zoai:scielo:S0100-40422018000800880Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2018-10-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
title LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
spellingShingle LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
Duarte,Susyanne L. F.
lignans
Phyllanthus
cytotoxicity
glioma cells
title_short LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
title_full LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
title_fullStr LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
title_full_unstemmed LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
title_sort LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
author Duarte,Susyanne L. F.
author_facet Duarte,Susyanne L. F.
Nascimento,Yuri M.
Madeiro,Sara A. L.
Costa,Vicente C. O.
Agra,Maria F.
Sobral,Marianna V.
Braz-Filho,Raimundo
Carvalho,Mario G.
Carvalho,João E.
Ruiz,Ana L. T. G.
Turri,Larissa S.
Silva,Marcelo S.
Tavares,Josean F.
author_role author
author2 Nascimento,Yuri M.
Madeiro,Sara A. L.
Costa,Vicente C. O.
Agra,Maria F.
Sobral,Marianna V.
Braz-Filho,Raimundo
Carvalho,Mario G.
Carvalho,João E.
Ruiz,Ana L. T. G.
Turri,Larissa S.
Silva,Marcelo S.
Tavares,Josean F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Duarte,Susyanne L. F.
Nascimento,Yuri M.
Madeiro,Sara A. L.
Costa,Vicente C. O.
Agra,Maria F.
Sobral,Marianna V.
Braz-Filho,Raimundo
Carvalho,Mario G.
Carvalho,João E.
Ruiz,Ana L. T. G.
Turri,Larissa S.
Silva,Marcelo S.
Tavares,Josean F.
dc.subject.por.fl_str_mv lignans
Phyllanthus
cytotoxicity
glioma cells
topic lignans
Phyllanthus
cytotoxicity
glioma cells
description The secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic activity of justicidin B was assessed against tumor cell lines (MCF-7, U251, NCI-ADR/RES, NCI-H460, OVCAR-3, HT29 and K562) and a non-tumor cell line (HaCat) using sulforhodamine B assay. Justicidin B showed strong cytotoxic activity against the tumor cell lines HT29, K562 and U251 with GI50 values of 2.28, 3.29 and 5.76 mol L-1, respectively.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018000800880
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422018000800880
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170266
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.41 n.8 2018
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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