Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile

Detalhes bibliográficos
Autor(a) principal: Okram,Zenita Devi
Data de Publicação: 2012
Outros Autores: Kanakapura,Basavaiah, Jagannathamurthy,Ramesh Pavagada, Basavaiah,Vinay Kanakapura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200027
Resumo: A UV-spectrophotometric method is described for the determination of lansoprazole (LAN). The method is based on the measurement of the absorbance of LAN solution in acetonitrile at 281 nm. The system obeyed Beer's law over the concentration range of 1.25-25.0 µg/mL. The degradation behavior of LAN was investigated under dry heat treatment, UV-degradation, acid hydrolysis, alkali hydrolysis and oxidation; and found to degrade extensively under acid hydrolysis, alkali hydrolysis and oxidation. The method was applied to the determination of LAN in capsule and the results were statistically compared with those of the reference method by applying Student's t-test and F-test.
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spelling Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profilelansoprazoleUV-spectrophotometric determinationdegradation studyA UV-spectrophotometric method is described for the determination of lansoprazole (LAN). The method is based on the measurement of the absorbance of LAN solution in acetonitrile at 281 nm. The system obeyed Beer's law over the concentration range of 1.25-25.0 µg/mL. The degradation behavior of LAN was investigated under dry heat treatment, UV-degradation, acid hydrolysis, alkali hydrolysis and oxidation; and found to degrade extensively under acid hydrolysis, alkali hydrolysis and oxidation. The method was applied to the determination of LAN in capsule and the results were statistically compared with those of the reference method by applying Student's t-test and F-test.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200027Química Nova v.35 n.2 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000200027info:eu-repo/semantics/openAccessOkram,Zenita DeviKanakapura,BasavaiahJagannathamurthy,Ramesh PavagadaBasavaiah,Vinay Kanakapuraeng2012-04-03T00:00:00Zoai:scielo:S0100-40422012000200027Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-04-03T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
title Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
spellingShingle Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
Okram,Zenita Devi
lansoprazole
UV-spectrophotometric determination
degradation study
title_short Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
title_full Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
title_fullStr Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
title_full_unstemmed Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
title_sort Development of a simple UV-spectrophotometric method for the determination of lansoprazole and study of its degradation profile
author Okram,Zenita Devi
author_facet Okram,Zenita Devi
Kanakapura,Basavaiah
Jagannathamurthy,Ramesh Pavagada
Basavaiah,Vinay Kanakapura
author_role author
author2 Kanakapura,Basavaiah
Jagannathamurthy,Ramesh Pavagada
Basavaiah,Vinay Kanakapura
author2_role author
author
author
dc.contributor.author.fl_str_mv Okram,Zenita Devi
Kanakapura,Basavaiah
Jagannathamurthy,Ramesh Pavagada
Basavaiah,Vinay Kanakapura
dc.subject.por.fl_str_mv lansoprazole
UV-spectrophotometric determination
degradation study
topic lansoprazole
UV-spectrophotometric determination
degradation study
description A UV-spectrophotometric method is described for the determination of lansoprazole (LAN). The method is based on the measurement of the absorbance of LAN solution in acetonitrile at 281 nm. The system obeyed Beer's law over the concentration range of 1.25-25.0 µg/mL. The degradation behavior of LAN was investigated under dry heat treatment, UV-degradation, acid hydrolysis, alkali hydrolysis and oxidation; and found to degrade extensively under acid hydrolysis, alkali hydrolysis and oxidation. The method was applied to the determination of LAN in capsule and the results were statistically compared with those of the reference method by applying Student's t-test and F-test.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200027
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000200027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000200027
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.2 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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