Avanços recentes na química dos aminoaçúcares: ocorrência, biossíntese, síntese e aplicação

• Autor(a) principal: Moura,Aldicéia Luiz de
• Data de Publicação: 2019
• Outros Autores: Guimarães,Bruna Martins, Lima,Josefa Aqueline da Cunha, Mata,Mauricélia M. Sousa, Silva,Jadson Farias da, Oliveira,Ronaldo N., Freitas,Juliano Carlo Rufino de, Freitas Filho,João R. de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Química Nova (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019004600642
• topic: carbohydrate; amino sugars; regioselectivity; diastereoselectivity

Amino sugars are chemical compounds that have a sugar backbone, in which one of the hydroxyl groups is replaced by an amino group. Derivatives of amine-containing sugars, such as N-acetylglucosamine, are also considered amino sugars. The synthetic introduction of amino functionalities in a regio- and stereoselective manner ontosugar scaffolds represents a substantial challenge. Most of the modern methods for the preparation of 1-, 2- and 3-amino sugars are those starting from glycals, 2,3-unsaturated O-glycosides epoxy-sugars, keto-sugars among others. This review summarizes recente developments in the current state of knowledge concerning the occurrence, biosynthesis, synthesis and application of amino sugars.