alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos

Detalhes bibliográficos
Autor(a) principal: Melo,Eduardo Borges de
Data de Publicação: 2006
Outros Autores: Carvalho,Ivone
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400036
Resumo: Glucosidases are involved in key steps in the processing of oligosaccharides by cleaving O-glucose residues. Since they catalyze breaking and transfer reactions of glucosidic groups for the normal growth and development of all the cells, defects or genetic deficiencies in these enzymes are associated with serious disorders of the carbohydrate metabolism. Thus, glucosidases represent important targets to develop inhibitors, owing to their potential activities against viruses, tumoral growth and metastasis, diabetes, Gaucher's disease and other syndromes associated with the lisosomal storage of glucoesphingolipids, and osteoarthritis. This paper presents a description of the biochemical pathways and mechanisms of alpha and beta-glucosidases, and the currently available drugs capable to inhibit these enzymes.
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spelling alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacosalpha and beta-glucosidasesdiabetes and Gaucher's diseasesHIVGlucosidases are involved in key steps in the processing of oligosaccharides by cleaving O-glucose residues. Since they catalyze breaking and transfer reactions of glucosidic groups for the normal growth and development of all the cells, defects or genetic deficiencies in these enzymes are associated with serious disorders of the carbohydrate metabolism. Thus, glucosidases represent important targets to develop inhibitors, owing to their potential activities against viruses, tumoral growth and metastasis, diabetes, Gaucher's disease and other syndromes associated with the lisosomal storage of glucoesphingolipids, and osteoarthritis. This paper presents a description of the biochemical pathways and mechanisms of alpha and beta-glucosidases, and the currently available drugs capable to inhibit these enzymes.Sociedade Brasileira de Química2006-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400036Química Nova v.29 n.4 2006reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422006000400036info:eu-repo/semantics/openAccessMelo,Eduardo Borges deCarvalho,Ivonepor2006-07-31T00:00:00Zoai:scielo:S0100-40422006000400036Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2006-07-31T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
title alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
spellingShingle alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
Melo,Eduardo Borges de
alpha and beta-glucosidases
diabetes and Gaucher's diseases
HIV
title_short alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
title_full alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
title_fullStr alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
title_full_unstemmed alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
title_sort alfa e b-glucosidases como alvos moleculares para desenvolvimento de fármacos
author Melo,Eduardo Borges de
author_facet Melo,Eduardo Borges de
Carvalho,Ivone
author_role author
author2 Carvalho,Ivone
author2_role author
dc.contributor.author.fl_str_mv Melo,Eduardo Borges de
Carvalho,Ivone
dc.subject.por.fl_str_mv alpha and beta-glucosidases
diabetes and Gaucher's diseases
HIV
topic alpha and beta-glucosidases
diabetes and Gaucher's diseases
HIV
description Glucosidases are involved in key steps in the processing of oligosaccharides by cleaving O-glucose residues. Since they catalyze breaking and transfer reactions of glucosidic groups for the normal growth and development of all the cells, defects or genetic deficiencies in these enzymes are associated with serious disorders of the carbohydrate metabolism. Thus, glucosidases represent important targets to develop inhibitors, owing to their potential activities against viruses, tumoral growth and metastasis, diabetes, Gaucher's disease and other syndromes associated with the lisosomal storage of glucoesphingolipids, and osteoarthritis. This paper presents a description of the biochemical pathways and mechanisms of alpha and beta-glucosidases, and the currently available drugs capable to inhibit these enzymes.
publishDate 2006
dc.date.none.fl_str_mv 2006-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400036
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400036
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422006000400036
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.29 n.4 2006
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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