First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000500570 |
Resumo: | Brazil has the greatest plant diversity in the world. Many species exhibit a wide range of phytochemical compounds which can be exploited in food, agronomic, pharmacological and medicinal plant industries. Therefore, the chemical composition and in vitro bioactivities of volatile oil from Psidium firmum fresh leaves (PfVO) were investigated for the first time. GC-FID and GC-MS analyses revealed 28 compounds in PfVO. The major ones were α-selinene (20.8%), β-caryophyllene (16.5%) and nerolidol (10.4%). Results showed that PfVO affected the growth of Leishmania amazonensis promastigote forms in a dose-dependent manner; its IC50 value was 14.05 µg/mL. PfVO also exhibited antibacterial activity against Salmonella enteritidis, Yersinia enterocolitica, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes; MIC values ranged from 25 μg/mL to 250 μg/mL. Moreover, PfVO promoted normal cell growth inhibition at 61.02 ± 1.97 µg/mL. Antiproliferative activity was observed against human tumor cell lines; IC50 values of MCF-7 cells, HeLa cells and M059J cells were 47.91 µg/mL, 73.78 µg/mL and 41.94 µg/mL, respectively. Results provided strong evidence of the promising potential of PfVO as a nature-based antileishmanial, antibacterial and antiproliferative agent. |
id |
SBQ-3_52ce8c3fe8d1a4b6fe335d6c49d60fcd |
---|---|
oai_identifier_str |
oai:scielo:S0100-40422021000500570 |
network_acronym_str |
SBQ-3 |
network_name_str |
Química Nova (Online) |
repository_id_str |
|
spelling |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leavesLeishmania amazonensisfoodborne bacteriatumor cell linesListeria monocytogenesYersinia enterocoliticaBrazil has the greatest plant diversity in the world. Many species exhibit a wide range of phytochemical compounds which can be exploited in food, agronomic, pharmacological and medicinal plant industries. Therefore, the chemical composition and in vitro bioactivities of volatile oil from Psidium firmum fresh leaves (PfVO) were investigated for the first time. GC-FID and GC-MS analyses revealed 28 compounds in PfVO. The major ones were α-selinene (20.8%), β-caryophyllene (16.5%) and nerolidol (10.4%). Results showed that PfVO affected the growth of Leishmania amazonensis promastigote forms in a dose-dependent manner; its IC50 value was 14.05 µg/mL. PfVO also exhibited antibacterial activity against Salmonella enteritidis, Yersinia enterocolitica, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes; MIC values ranged from 25 μg/mL to 250 μg/mL. Moreover, PfVO promoted normal cell growth inhibition at 61.02 ± 1.97 µg/mL. Antiproliferative activity was observed against human tumor cell lines; IC50 values of MCF-7 cells, HeLa cells and M059J cells were 47.91 µg/mL, 73.78 µg/mL and 41.94 µg/mL, respectively. Results provided strong evidence of the promising potential of PfVO as a nature-based antileishmanial, antibacterial and antiproliferative agent.Sociedade Brasileira de Química2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000500570Química Nova v.44 n.5 2021reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170710info:eu-repo/semantics/openAccessFernandes,Cassia CristinaChrystal,PietroPereira,Alexandra CristineColli,Ana CarlaStenico,LiviaRibeiro,Arthur BarcelosSquarisi,Iara SilvaCandido,Ana Carolina Bolela BovoTavares,Denise CrispimMagalhães,Lizandra GuidiCrotti,Antônio Eduardo MillerMartins,Carlos Henrique GomesMiranda,Mayker Lazaro Dantaseng2022-03-23T00:00:00Zoai:scielo:S0100-40422021000500570Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2022-03-23T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
title |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
spellingShingle |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves Fernandes,Cassia Cristina Leishmania amazonensis foodborne bacteria tumor cell lines Listeria monocytogenes Yersinia enterocolitica |
title_short |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
title_full |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
title_fullStr |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
title_full_unstemmed |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
title_sort |
First report on chemical composition and biological properties of volatile oil from Psidium firmum O. Berg leaves |
author |
Fernandes,Cassia Cristina |
author_facet |
Fernandes,Cassia Cristina Chrystal,Pietro Pereira,Alexandra Cristine Colli,Ana Carla Stenico,Livia Ribeiro,Arthur Barcelos Squarisi,Iara Silva Candido,Ana Carolina Bolela Bovo Tavares,Denise Crispim Magalhães,Lizandra Guidi Crotti,Antônio Eduardo Miller Martins,Carlos Henrique Gomes Miranda,Mayker Lazaro Dantas |
author_role |
author |
author2 |
Chrystal,Pietro Pereira,Alexandra Cristine Colli,Ana Carla Stenico,Livia Ribeiro,Arthur Barcelos Squarisi,Iara Silva Candido,Ana Carolina Bolela Bovo Tavares,Denise Crispim Magalhães,Lizandra Guidi Crotti,Antônio Eduardo Miller Martins,Carlos Henrique Gomes Miranda,Mayker Lazaro Dantas |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes,Cassia Cristina Chrystal,Pietro Pereira,Alexandra Cristine Colli,Ana Carla Stenico,Livia Ribeiro,Arthur Barcelos Squarisi,Iara Silva Candido,Ana Carolina Bolela Bovo Tavares,Denise Crispim Magalhães,Lizandra Guidi Crotti,Antônio Eduardo Miller Martins,Carlos Henrique Gomes Miranda,Mayker Lazaro Dantas |
dc.subject.por.fl_str_mv |
Leishmania amazonensis foodborne bacteria tumor cell lines Listeria monocytogenes Yersinia enterocolitica |
topic |
Leishmania amazonensis foodborne bacteria tumor cell lines Listeria monocytogenes Yersinia enterocolitica |
description |
Brazil has the greatest plant diversity in the world. Many species exhibit a wide range of phytochemical compounds which can be exploited in food, agronomic, pharmacological and medicinal plant industries. Therefore, the chemical composition and in vitro bioactivities of volatile oil from Psidium firmum fresh leaves (PfVO) were investigated for the first time. GC-FID and GC-MS analyses revealed 28 compounds in PfVO. The major ones were α-selinene (20.8%), β-caryophyllene (16.5%) and nerolidol (10.4%). Results showed that PfVO affected the growth of Leishmania amazonensis promastigote forms in a dose-dependent manner; its IC50 value was 14.05 µg/mL. PfVO also exhibited antibacterial activity against Salmonella enteritidis, Yersinia enterocolitica, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes; MIC values ranged from 25 μg/mL to 250 μg/mL. Moreover, PfVO promoted normal cell growth inhibition at 61.02 ± 1.97 µg/mL. Antiproliferative activity was observed against human tumor cell lines; IC50 values of MCF-7 cells, HeLa cells and M059J cells were 47.91 µg/mL, 73.78 µg/mL and 41.94 µg/mL, respectively. Results provided strong evidence of the promising potential of PfVO as a nature-based antileishmanial, antibacterial and antiproliferative agent. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000500570 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000500570 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170710 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.44 n.5 2021 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318121105752064 |