Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

Detalhes bibliográficos
Autor(a) principal: Schmidt Jr,Erlando
Data de Publicação: 2011
Outros Autores: Melchert,Wanessa R, Rocha,Fábio R. P
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019
Resumo: A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.
id SBQ-3_53f561bb2691363da4eb143f015d8893
oai_identifier_str oai:scielo:S0100-40422011000700019
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacosflow analysispharmaceuticalssequential determinationA flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019Química Nova v.34 n.7 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000700019info:eu-repo/semantics/openAccessSchmidt Jr,ErlandoMelchert,Wanessa RRocha,Fábio R. Ppor2011-09-12T00:00:00Zoai:scielo:S0100-40422011000700019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-09-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
title Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
spellingShingle Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
Schmidt Jr,Erlando
flow analysis
pharmaceuticals
sequential determination
title_short Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
title_full Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
title_fullStr Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
title_full_unstemmed Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
title_sort Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos
author Schmidt Jr,Erlando
author_facet Schmidt Jr,Erlando
Melchert,Wanessa R
Rocha,Fábio R. P
author_role author
author2 Melchert,Wanessa R
Rocha,Fábio R. P
author2_role author
author
dc.contributor.author.fl_str_mv Schmidt Jr,Erlando
Melchert,Wanessa R
Rocha,Fábio R. P
dc.subject.por.fl_str_mv flow analysis
pharmaceuticals
sequential determination
topic flow analysis
pharmaceuticals
sequential determination
description A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700019
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000700019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.7 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318112363773952

Registros relacionados