Síntese de glicoaminoácidos de interesse biológico

Detalhes bibliográficos
Autor(a) principal: Campo,Vanessa Leiria
Data de Publicação: 2008
Outros Autores: Carvalho,Ivone
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500015
Resumo: This work describes the synthesis of the glycosylated amino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thr by the glycosylation reaction of the amino acid threonine with the corresponding glycosyl donors αGlcNAcCl and αLacN3Cl. The glycosylated amino acids containing the sugar units α-D-GlcNAc and α-D-LacNAc O-linked to threonine amino acids are related to O-glycans found in mucins of the parasite Trypanosoma cruzi, while the corresponding β-D-GlcNAc isomer is involved in cellular signaling events.
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spelling Síntese de glicoaminoácidos de interesse biológicoglycosylated amino acidsglycosyl donorsglycosylation reactionThis work describes the synthesis of the glycosylated amino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thr by the glycosylation reaction of the amino acid threonine with the corresponding glycosyl donors αGlcNAcCl and αLacN3Cl. The glycosylated amino acids containing the sugar units α-D-GlcNAc and α-D-LacNAc O-linked to threonine amino acids are related to O-glycans found in mucins of the parasite Trypanosoma cruzi, while the corresponding β-D-GlcNAc isomer is involved in cellular signaling events.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500015Química Nova v.31 n.5 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000500015info:eu-repo/semantics/openAccessCampo,Vanessa LeiriaCarvalho,Ivonepor2008-09-12T00:00:00Zoai:scielo:S0100-40422008000500015Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-09-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Síntese de glicoaminoácidos de interesse biológico
title Síntese de glicoaminoácidos de interesse biológico
spellingShingle Síntese de glicoaminoácidos de interesse biológico
Campo,Vanessa Leiria
glycosylated amino acids
glycosyl donors
glycosylation reaction
title_short Síntese de glicoaminoácidos de interesse biológico
title_full Síntese de glicoaminoácidos de interesse biológico
title_fullStr Síntese de glicoaminoácidos de interesse biológico
title_full_unstemmed Síntese de glicoaminoácidos de interesse biológico
title_sort Síntese de glicoaminoácidos de interesse biológico
author Campo,Vanessa Leiria
author_facet Campo,Vanessa Leiria
Carvalho,Ivone
author_role author
author2 Carvalho,Ivone
author2_role author
dc.contributor.author.fl_str_mv Campo,Vanessa Leiria
Carvalho,Ivone
dc.subject.por.fl_str_mv glycosylated amino acids
glycosyl donors
glycosylation reaction
topic glycosylated amino acids
glycosyl donors
glycosylation reaction
description This work describes the synthesis of the glycosylated amino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thr by the glycosylation reaction of the amino acid threonine with the corresponding glycosyl donors αGlcNAcCl and αLacN3Cl. The glycosylated amino acids containing the sugar units α-D-GlcNAc and α-D-LacNAc O-linked to threonine amino acids are related to O-glycans found in mucins of the parasite Trypanosoma cruzi, while the corresponding β-D-GlcNAc isomer is involved in cellular signaling events.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000500015
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000500015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.5 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318107645181952

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