Proteínas quinases: características estruturais e inibidores químicos

Detalhes bibliográficos
Autor(a) principal: Silva,Bárbara V.
Data de Publicação: 2009
Outros Autores: Horta,Bruno A. C., Alencastro,Ricardo Bicca de, Pinto,Angelo C.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000200032
Resumo: Protein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues. Deregulation of these enzymes is associated with several diseases including cancer, diabetes and inflammation. For this reason, specific inhibition of tyrosine or serine/threonine kinases may represent an interesting therapeutic approach. The most important types of protein kinases, their structural features and chemical inhibitors are discussed in this paper. Emphasis is given to the small-molecule drugs that target the ATP-binding sites of these enzymes.
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spelling Proteínas quinases: características estruturais e inibidores químicoskinasechemical inhibitorscell signalingProtein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues. Deregulation of these enzymes is associated with several diseases including cancer, diabetes and inflammation. For this reason, specific inhibition of tyrosine or serine/threonine kinases may represent an interesting therapeutic approach. The most important types of protein kinases, their structural features and chemical inhibitors are discussed in this paper. Emphasis is given to the small-molecule drugs that target the ATP-binding sites of these enzymes.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000200032Química Nova v.32 n.2 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000200032info:eu-repo/semantics/openAccessSilva,Bárbara V.Horta,Bruno A. C.Alencastro,Ricardo Bicca dePinto,Angelo C.por2009-04-23T00:00:00Zoai:scielo:S0100-40422009000200032Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-04-23T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Proteínas quinases: características estruturais e inibidores químicos
title Proteínas quinases: características estruturais e inibidores químicos
spellingShingle Proteínas quinases: características estruturais e inibidores químicos
Silva,Bárbara V.
kinase
chemical inhibitors
cell signaling
title_short Proteínas quinases: características estruturais e inibidores químicos
title_full Proteínas quinases: características estruturais e inibidores químicos
title_fullStr Proteínas quinases: características estruturais e inibidores químicos
title_full_unstemmed Proteínas quinases: características estruturais e inibidores químicos
title_sort Proteínas quinases: características estruturais e inibidores químicos
author Silva,Bárbara V.
author_facet Silva,Bárbara V.
Horta,Bruno A. C.
Alencastro,Ricardo Bicca de
Pinto,Angelo C.
author_role author
author2 Horta,Bruno A. C.
Alencastro,Ricardo Bicca de
Pinto,Angelo C.
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Bárbara V.
Horta,Bruno A. C.
Alencastro,Ricardo Bicca de
Pinto,Angelo C.
dc.subject.por.fl_str_mv kinase
chemical inhibitors
cell signaling
topic kinase
chemical inhibitors
cell signaling
description Protein kinases are one of the largest protein families and they are responsible for regulation of a great number of signal transduction pathways in cells, through the phosphorylation of serine, threonine, or tyrosine residues. Deregulation of these enzymes is associated with several diseases including cancer, diabetes and inflammation. For this reason, specific inhibition of tyrosine or serine/threonine kinases may represent an interesting therapeutic approach. The most important types of protein kinases, their structural features and chemical inhibitors are discussed in this paper. Emphasis is given to the small-molecule drugs that target the ATP-binding sites of these enzymes.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000200032
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000200032
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000200032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.2 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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