Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos

Detalhes bibliográficos
Autor(a) principal: Paulai,Fávero Reisdorfer
Data de Publicação: 2009
Outros Autores: Serrano,Silvia Helena Pires, Tavares,Leoberto Costa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400032
Resumo: Nitrocompounds are bioactive molecules used as antibacterial, antiparasitic and antitumoral agents. In the past of years, these molecules have been broadly studied in several fields, such as medicinal chemistry, organic chemistry, biochemical, toxicology and electrochemistry. The nitrocompounds mode of action involves the biotransformation of the nitro group, releasing intermediates in the redox process. Some of those intermediates attack enzymes, membranes and DNA, providing the basis for their biological activity and adverse effects. In this report, some aspects regarding the biological activity, mechanism of action and toxicity of nitrocompounds are explored, purposing the research of new bioactive derivatives having low toxicity.
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spelling Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostosnitrocompoundstoxic radicalsbiological activityNitrocompounds are bioactive molecules used as antibacterial, antiparasitic and antitumoral agents. In the past of years, these molecules have been broadly studied in several fields, such as medicinal chemistry, organic chemistry, biochemical, toxicology and electrochemistry. The nitrocompounds mode of action involves the biotransformation of the nitro group, releasing intermediates in the redox process. Some of those intermediates attack enzymes, membranes and DNA, providing the basis for their biological activity and adverse effects. In this report, some aspects regarding the biological activity, mechanism of action and toxicity of nitrocompounds are explored, purposing the research of new bioactive derivatives having low toxicity.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400032Química Nova v.32 n.4 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000400032info:eu-repo/semantics/openAccessPaulai,Fávero ReisdorferSerrano,Silvia Helena PiresTavares,Leoberto Costapor2009-06-09T00:00:00Zoai:scielo:S0100-40422009000400032Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-06-09T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
title Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
spellingShingle Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
Paulai,Fávero Reisdorfer
nitrocompounds
toxic radicals
biological activity
title_short Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
title_full Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
title_fullStr Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
title_full_unstemmed Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
title_sort Aspectos mecanísticos da bioatividade e toxicidade de nitrocompostos
author Paulai,Fávero Reisdorfer
author_facet Paulai,Fávero Reisdorfer
Serrano,Silvia Helena Pires
Tavares,Leoberto Costa
author_role author
author2 Serrano,Silvia Helena Pires
Tavares,Leoberto Costa
author2_role author
author
dc.contributor.author.fl_str_mv Paulai,Fávero Reisdorfer
Serrano,Silvia Helena Pires
Tavares,Leoberto Costa
dc.subject.por.fl_str_mv nitrocompounds
toxic radicals
biological activity
topic nitrocompounds
toxic radicals
biological activity
description Nitrocompounds are bioactive molecules used as antibacterial, antiparasitic and antitumoral agents. In the past of years, these molecules have been broadly studied in several fields, such as medicinal chemistry, organic chemistry, biochemical, toxicology and electrochemistry. The nitrocompounds mode of action involves the biotransformation of the nitro group, releasing intermediates in the redox process. Some of those intermediates attack enzymes, membranes and DNA, providing the basis for their biological activity and adverse effects. In this report, some aspects regarding the biological activity, mechanism of action and toxicity of nitrocompounds are explored, purposing the research of new bioactive derivatives having low toxicity.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400032
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400032
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000400032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.4 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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