Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness

Detalhes bibliográficos
Autor(a) principal: Paim,Clésio Soldateli
Data de Publicação: 2012
Outros Autores: Führ,Fernanda, Steppe,Martin, Schapoval,Elfrides Eva Scherman
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100033
Resumo: This study describes the validation of UV spectrophotometric method for quantitative determination of gemifloxacin mesylate (GFM) in tablets using methanol as solvent. The method was specific, linear, precise, exact and robust at 272 and 343 nm. The results confirmed that the method in both wavelengths is valid and useful to the routine quality control of GFM in coated tablets. The validate method was compared to liquid chromatography (HPLC), microbiological assay and visible (VIS) spectrophotometry, which were previously developed and validated to the same drug. There was not significative difference between the methods for GFM quantitation.
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spelling Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustnessexperimental designgemifloxacin mesylateUV spectrophotometric methodThis study describes the validation of UV spectrophotometric method for quantitative determination of gemifloxacin mesylate (GFM) in tablets using methanol as solvent. The method was specific, linear, precise, exact and robust at 272 and 343 nm. The results confirmed that the method in both wavelengths is valid and useful to the routine quality control of GFM in coated tablets. The validate method was compared to liquid chromatography (HPLC), microbiological assay and visible (VIS) spectrophotometry, which were previously developed and validated to the same drug. There was not significative difference between the methods for GFM quantitation.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100033Química Nova v.35 n.1 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000100033info:eu-repo/semantics/openAccessPaim,Clésio SoldateliFühr,FernandaSteppe,MartinSchapoval,Elfrides Eva Schermaneng2012-02-27T00:00:00Zoai:scielo:S0100-40422012000100033Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-02-27T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
title Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
spellingShingle Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
Paim,Clésio Soldateli
experimental design
gemifloxacin mesylate
UV spectrophotometric method
title_short Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
title_full Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
title_fullStr Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
title_full_unstemmed Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
title_sort Gemifloxacin mesylate: UV spectrophotometric method for quantitative determination using experimental design for robustness
author Paim,Clésio Soldateli
author_facet Paim,Clésio Soldateli
Führ,Fernanda
Steppe,Martin
Schapoval,Elfrides Eva Scherman
author_role author
author2 Führ,Fernanda
Steppe,Martin
Schapoval,Elfrides Eva Scherman
author2_role author
author
author
dc.contributor.author.fl_str_mv Paim,Clésio Soldateli
Führ,Fernanda
Steppe,Martin
Schapoval,Elfrides Eva Scherman
dc.subject.por.fl_str_mv experimental design
gemifloxacin mesylate
UV spectrophotometric method
topic experimental design
gemifloxacin mesylate
UV spectrophotometric method
description This study describes the validation of UV spectrophotometric method for quantitative determination of gemifloxacin mesylate (GFM) in tablets using methanol as solvent. The method was specific, linear, precise, exact and robust at 272 and 343 nm. The results confirmed that the method in both wavelengths is valid and useful to the routine quality control of GFM in coated tablets. The validate method was compared to liquid chromatography (HPLC), microbiological assay and visible (VIS) spectrophotometry, which were previously developed and validated to the same drug. There was not significative difference between the methods for GFM quantitation.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100033
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000100033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.1 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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