Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Detalhes bibliográficos
Autor(a) principal: Cardoso,Sílvia H.
Data de Publicação: 2009
Outros Autores: Assis,João Vítor de, Almeida,Mauro V. de, Lourenço,Maria Cristina S., Vicente,Felipe R. C., Souza,Marcus V. N. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000600038
Resumo: A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.
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spelling Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivativesisoniazid analogscarbohydrateantimycobacterial activityA series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000600038Química Nova v.32 n.6 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000600038info:eu-repo/semantics/openAccessCardoso,Sílvia H.Assis,João Vítor deAlmeida,Mauro V. deLourenço,Maria Cristina S.Vicente,Felipe R. C.Souza,Marcus V. N. deeng2009-09-22T00:00:00Zoai:scielo:S0100-40422009000600038Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-09-22T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
spellingShingle Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
Cardoso,Sílvia H.
isoniazid analogs
carbohydrate
antimycobacterial activity
title_short Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_full Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_fullStr Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_full_unstemmed Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
title_sort Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
author Cardoso,Sílvia H.
author_facet Cardoso,Sílvia H.
Assis,João Vítor de
Almeida,Mauro V. de
Lourenço,Maria Cristina S.
Vicente,Felipe R. C.
Souza,Marcus V. N. de
author_role author
author2 Assis,João Vítor de
Almeida,Mauro V. de
Lourenço,Maria Cristina S.
Vicente,Felipe R. C.
Souza,Marcus V. N. de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso,Sílvia H.
Assis,João Vítor de
Almeida,Mauro V. de
Lourenço,Maria Cristina S.
Vicente,Felipe R. C.
Souza,Marcus V. N. de
dc.subject.por.fl_str_mv isoniazid analogs
carbohydrate
antimycobacterial activity
topic isoniazid analogs
carbohydrate
antimycobacterial activity
description A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000600038
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000600038
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000600038
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.6 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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