3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000400462 |
Resumo: | Porous synthetic substrates are developed through tissue engineering technologies to grow new tissue, restoring the function of tissue or an organ. For bone regeneration, these scaffolds must support the dynamic load exerted on this tissue, achieved primarily by increasing their compression strength, as established in the literature. The aim of this paper was to incorporate an inorganic composite bioactive glass (60%SiO2 - 36%CaO - 4%P2O5) as a reinforcing agent in mechanical 3D scaffolds that must remain porous. Two strategies were adopted: a co-precipitation method to obtain a nanoparticulate dispersion of bioactive glass (BGNP) and a sol-gel method to combine a bioactive glass solution (BG) with a previously prepared chitosan polymer solution. Moreover, a lyophilization process was also used, generating highly porous scaffolds. Various aspects of the scaffold were evaluated, including the morphology, orientation and size of the pores, and mechanical strength, as obtained using the two synthetic methods. The data for compressive strength revealed increased strength after the incorporation of bioactive glass, which was more pronounced when utilizing the nanoscale bioactive glass. |
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3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical propertiesporous scaffoldsbioactive glassnanoparticleslyophilizationPorous synthetic substrates are developed through tissue engineering technologies to grow new tissue, restoring the function of tissue or an organ. For bone regeneration, these scaffolds must support the dynamic load exerted on this tissue, achieved primarily by increasing their compression strength, as established in the literature. The aim of this paper was to incorporate an inorganic composite bioactive glass (60%SiO2 - 36%CaO - 4%P2O5) as a reinforcing agent in mechanical 3D scaffolds that must remain porous. Two strategies were adopted: a co-precipitation method to obtain a nanoparticulate dispersion of bioactive glass (BGNP) and a sol-gel method to combine a bioactive glass solution (BG) with a previously prepared chitosan polymer solution. Moreover, a lyophilization process was also used, generating highly porous scaffolds. Various aspects of the scaffold were evaluated, including the morphology, orientation and size of the pores, and mechanical strength, as obtained using the two synthetic methods. The data for compressive strength revealed increased strength after the incorporation of bioactive glass, which was more pronounced when utilizing the nanoscale bioactive glass.Sociedade Brasileira de Química2016-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000400462Química Nova v.39 n.4 2016reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20160047info:eu-repo/semantics/openAccessLemos,Elke M. F.Patrício,Patrícia S. O.Pereira,Marivalda M.eng2016-05-25T00:00:00Zoai:scielo:S0100-40422016000400462Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2016-05-25T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
title |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
spellingShingle |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties Lemos,Elke M. F. porous scaffolds bioactive glass nanoparticles lyophilization |
title_short |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
title_full |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
title_fullStr |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
title_full_unstemmed |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
title_sort |
3D nanocomposite chitosan/bioactive glass scaffolds obtained using two different routes: an evaluation of the porous structure and mechanical properties |
author |
Lemos,Elke M. F. |
author_facet |
Lemos,Elke M. F. Patrício,Patrícia S. O. Pereira,Marivalda M. |
author_role |
author |
author2 |
Patrício,Patrícia S. O. Pereira,Marivalda M. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Lemos,Elke M. F. Patrício,Patrícia S. O. Pereira,Marivalda M. |
dc.subject.por.fl_str_mv |
porous scaffolds bioactive glass nanoparticles lyophilization |
topic |
porous scaffolds bioactive glass nanoparticles lyophilization |
description |
Porous synthetic substrates are developed through tissue engineering technologies to grow new tissue, restoring the function of tissue or an organ. For bone regeneration, these scaffolds must support the dynamic load exerted on this tissue, achieved primarily by increasing their compression strength, as established in the literature. The aim of this paper was to incorporate an inorganic composite bioactive glass (60%SiO2 - 36%CaO - 4%P2O5) as a reinforcing agent in mechanical 3D scaffolds that must remain porous. Two strategies were adopted: a co-precipitation method to obtain a nanoparticulate dispersion of bioactive glass (BGNP) and a sol-gel method to combine a bioactive glass solution (BG) with a previously prepared chitosan polymer solution. Moreover, a lyophilization process was also used, generating highly porous scaffolds. Various aspects of the scaffold were evaluated, including the morphology, orientation and size of the pores, and mechanical strength, as obtained using the two synthetic methods. The data for compressive strength revealed increased strength after the incorporation of bioactive glass, which was more pronounced when utilizing the nanoscale bioactive glass. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000400462 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000400462 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0100-4042.20160047 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.39 n.4 2016 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318117497602048 |