Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus

Detalhes bibliográficos
Autor(a) principal: Ambrozin,Alessandra Regina Pepe
Data de Publicação: 2008
Outros Autores: Vieira,Paulo Cezar, Fernandes,João Batista, Silva,Maria Fátima das Graças Fernandes da, Albuquerque,Sérgio de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400005
Resumo: The phytochemical investigation of trypanocidal extracts from leaves and stems of Conchocarpus heterophyllus (A. St.-Hil.) Kallunki & Pirani (Rutaceae) afforded new pyranoflavones along with the known compounds flavone, 7-methoxyflavone, 5-hydroxyflavone, haplotusine, 1-methyl-2-phenyl-4-quinolone alkaloid, beta-sitosterol, stigmasterol, and beta-sitosteryl benzoate. Their structures were established based on their spectral data. NMR data for the alkaloid haplotusine and the new pyranoflavones are described for the first time herein. These compounds were assayed on the tripomastigote forms of Trypanosoma cruzi. Among them, haplotusine and 1-methyl-2-phenyl-4-quinolone showed moderate values of IC50 136.9 and 144.9 mM, respectively.
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spelling Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllusConchocarpus heterophyllustrypanocidal activitypyranoflavonesThe phytochemical investigation of trypanocidal extracts from leaves and stems of Conchocarpus heterophyllus (A. St.-Hil.) Kallunki & Pirani (Rutaceae) afforded new pyranoflavones along with the known compounds flavone, 7-methoxyflavone, 5-hydroxyflavone, haplotusine, 1-methyl-2-phenyl-4-quinolone alkaloid, beta-sitosterol, stigmasterol, and beta-sitosteryl benzoate. Their structures were established based on their spectral data. NMR data for the alkaloid haplotusine and the new pyranoflavones are described for the first time herein. These compounds were assayed on the tripomastigote forms of Trypanosoma cruzi. Among them, haplotusine and 1-methyl-2-phenyl-4-quinolone showed moderate values of IC50 136.9 and 144.9 mM, respectively.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400005Química Nova v.31 n.4 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000400005info:eu-repo/semantics/openAccessAmbrozin,Alessandra Regina PepeVieira,Paulo CezarFernandes,João BatistaSilva,Maria Fátima das Graças Fernandes daAlbuquerque,Sérgio depor2008-06-16T00:00:00Zoai:scielo:S0100-40422008000400005Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-06-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
title Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
spellingShingle Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
Ambrozin,Alessandra Regina Pepe
Conchocarpus heterophyllus
trypanocidal activity
pyranoflavones
title_short Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
title_full Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
title_fullStr Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
title_full_unstemmed Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
title_sort Piranoflavonas inéditas e atividades tripanocidas das substâncias isoladas de conchocarpus heterophyllus
author Ambrozin,Alessandra Regina Pepe
author_facet Ambrozin,Alessandra Regina Pepe
Vieira,Paulo Cezar
Fernandes,João Batista
Silva,Maria Fátima das Graças Fernandes da
Albuquerque,Sérgio de
author_role author
author2 Vieira,Paulo Cezar
Fernandes,João Batista
Silva,Maria Fátima das Graças Fernandes da
Albuquerque,Sérgio de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ambrozin,Alessandra Regina Pepe
Vieira,Paulo Cezar
Fernandes,João Batista
Silva,Maria Fátima das Graças Fernandes da
Albuquerque,Sérgio de
dc.subject.por.fl_str_mv Conchocarpus heterophyllus
trypanocidal activity
pyranoflavones
topic Conchocarpus heterophyllus
trypanocidal activity
pyranoflavones
description The phytochemical investigation of trypanocidal extracts from leaves and stems of Conchocarpus heterophyllus (A. St.-Hil.) Kallunki & Pirani (Rutaceae) afforded new pyranoflavones along with the known compounds flavone, 7-methoxyflavone, 5-hydroxyflavone, haplotusine, 1-methyl-2-phenyl-4-quinolone alkaloid, beta-sitosterol, stigmasterol, and beta-sitosteryl benzoate. Their structures were established based on their spectral data. NMR data for the alkaloid haplotusine and the new pyranoflavones are described for the first time herein. These compounds were assayed on the tripomastigote forms of Trypanosoma cruzi. Among them, haplotusine and 1-methyl-2-phenyl-4-quinolone showed moderate values of IC50 136.9 and 144.9 mM, respectively.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400005
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.4 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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