Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach

Detalhes bibliográficos
Autor(a) principal: Ruidiaz,Miller A
Data de Publicação: 2011
Outros Autores: Delgado,Daniel R, Martínez,Fleming
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900016
Resumo: Extended Hildebrand Solubility Approach (EHSA) was successfully applied to evaluate the solubility of Indomethacin in 1,4-dioxane + water mixtures at 298.15 K. An acceptable correlation-performance of EHSA was found by using a regular polynomial model in order four of the W interaction parameter vs. solubility parameter of the mixtures (overall deviation was 8.9%). Although the mean deviation obtained was similar to that obtained directly by means of an empiric regression of the experimental solubility vs. mixtures solubility parameters, the advantages of EHSA are evident because it requires physicochemical properties easily available for drugs.
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spelling Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approachExtended Hildebrand Solubility Approachindomethacinsolubility parameterExtended Hildebrand Solubility Approach (EHSA) was successfully applied to evaluate the solubility of Indomethacin in 1,4-dioxane + water mixtures at 298.15 K. An acceptable correlation-performance of EHSA was found by using a regular polynomial model in order four of the W interaction parameter vs. solubility parameter of the mixtures (overall deviation was 8.9%). Although the mean deviation obtained was similar to that obtained directly by means of an empiric regression of the experimental solubility vs. mixtures solubility parameters, the advantages of EHSA are evident because it requires physicochemical properties easily available for drugs.Sociedade Brasileira de Química2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900016Química Nova v.34 n.9 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000900016info:eu-repo/semantics/openAccessRuidiaz,Miller ADelgado,Daniel RMartínez,Flemingeng2011-11-16T00:00:00Zoai:scielo:S0100-40422011000900016Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-11-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
title Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
spellingShingle Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
Ruidiaz,Miller A
Extended Hildebrand Solubility Approach
indomethacin
solubility parameter
title_short Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
title_full Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
title_fullStr Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
title_full_unstemmed Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
title_sort Indomethacin solubility estimation in 1,4-dioxane + water mixtures by the extended hildebrand solubility approach
author Ruidiaz,Miller A
author_facet Ruidiaz,Miller A
Delgado,Daniel R
Martínez,Fleming
author_role author
author2 Delgado,Daniel R
Martínez,Fleming
author2_role author
author
dc.contributor.author.fl_str_mv Ruidiaz,Miller A
Delgado,Daniel R
Martínez,Fleming
dc.subject.por.fl_str_mv Extended Hildebrand Solubility Approach
indomethacin
solubility parameter
topic Extended Hildebrand Solubility Approach
indomethacin
solubility parameter
description Extended Hildebrand Solubility Approach (EHSA) was successfully applied to evaluate the solubility of Indomethacin in 1,4-dioxane + water mixtures at 298.15 K. An acceptable correlation-performance of EHSA was found by using a regular polynomial model in order four of the W interaction parameter vs. solubility parameter of the mixtures (overall deviation was 8.9%). Although the mean deviation obtained was similar to that obtained directly by means of an empiric regression of the experimental solubility vs. mixtures solubility parameters, the advantages of EHSA are evident because it requires physicochemical properties easily available for drugs.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000900016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000900016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.9 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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