SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100057 |
Resumo: | Superparamagnetic iron oxide nanoparticles are suitable contrast agents for magnetic resonance imaging due to their effect on proton relaxation times, and excellent biocompatibility and biodistribution in tissue. In the present study, a ferrofluid formed by dextran-coated iron oxide nanoparticles was prepared by the coprecipitation method and with subsequent steps of crosslinking and addition of functionalizations on the nanoparticle's surface (amino groups and a fluorophore). The effect of differences in the synthesis route (ratio of dextran to iron salts and temperature of the reaction) on the physico-chemical characteristics of the nanoparticles and their performance as contrast agents for magnetic resonance imaging was investigated. Overall, the nuclear magnetic relaxation times of water protons in aqueous suspensions of the nanoparticles did not show major differences among different batches, with no significant effect due to the addition of the fluorophore or changes in the dextran fraction of up to 50%. Larger reductions in the ratio of dextran to iron salts resulted in particles with slightly larger sizes, higher saturation magnetization and distinct nuclear magnetic relaxation times. |
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SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLESnanoparticlesbiomedical imagingcontrast agentsSuperparamagnetic iron oxide nanoparticles are suitable contrast agents for magnetic resonance imaging due to their effect on proton relaxation times, and excellent biocompatibility and biodistribution in tissue. In the present study, a ferrofluid formed by dextran-coated iron oxide nanoparticles was prepared by the coprecipitation method and with subsequent steps of crosslinking and addition of functionalizations on the nanoparticle's surface (amino groups and a fluorophore). The effect of differences in the synthesis route (ratio of dextran to iron salts and temperature of the reaction) on the physico-chemical characteristics of the nanoparticles and their performance as contrast agents for magnetic resonance imaging was investigated. Overall, the nuclear magnetic relaxation times of water protons in aqueous suspensions of the nanoparticles did not show major differences among different batches, with no significant effect due to the addition of the fluorophore or changes in the dextran fraction of up to 50%. Larger reductions in the ratio of dextran to iron salts resulted in particles with slightly larger sizes, higher saturation magnetization and distinct nuclear magnetic relaxation times.Sociedade Brasileira de Química2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100057Química Nova v.42 n.1 2019reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170309info:eu-repo/semantics/openAccessOliveira,Elisa M. N. deRocha,Maximiliano S. daFroner,Ana Paula P.Basso,Nara R. S.Zanini,Mara L.Papaléo,Ricardo M.eng2019-02-20T00:00:00Zoai:scielo:S0100-40422019000100057Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2019-02-20T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
title |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
spellingShingle |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES Oliveira,Elisa M. N. de nanoparticles biomedical imaging contrast agents |
title_short |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
title_full |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
title_fullStr |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
title_full_unstemmed |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
title_sort |
SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES |
author |
Oliveira,Elisa M. N. de |
author_facet |
Oliveira,Elisa M. N. de Rocha,Maximiliano S. da Froner,Ana Paula P. Basso,Nara R. S. Zanini,Mara L. Papaléo,Ricardo M. |
author_role |
author |
author2 |
Rocha,Maximiliano S. da Froner,Ana Paula P. Basso,Nara R. S. Zanini,Mara L. Papaléo,Ricardo M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Elisa M. N. de Rocha,Maximiliano S. da Froner,Ana Paula P. Basso,Nara R. S. Zanini,Mara L. Papaléo,Ricardo M. |
dc.subject.por.fl_str_mv |
nanoparticles biomedical imaging contrast agents |
topic |
nanoparticles biomedical imaging contrast agents |
description |
Superparamagnetic iron oxide nanoparticles are suitable contrast agents for magnetic resonance imaging due to their effect on proton relaxation times, and excellent biocompatibility and biodistribution in tissue. In the present study, a ferrofluid formed by dextran-coated iron oxide nanoparticles was prepared by the coprecipitation method and with subsequent steps of crosslinking and addition of functionalizations on the nanoparticle's surface (amino groups and a fluorophore). The effect of differences in the synthesis route (ratio of dextran to iron salts and temperature of the reaction) on the physico-chemical characteristics of the nanoparticles and their performance as contrast agents for magnetic resonance imaging was investigated. Overall, the nuclear magnetic relaxation times of water protons in aqueous suspensions of the nanoparticles did not show major differences among different batches, with no significant effect due to the addition of the fluorophore or changes in the dextran fraction of up to 50%. Larger reductions in the ratio of dextran to iron salts resulted in particles with slightly larger sizes, higher saturation magnetization and distinct nuclear magnetic relaxation times. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100057 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000100057 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0100-4042.20170309 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.42 n.1 2019 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
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1750318119305347072 |