Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology

Detalhes bibliográficos
Autor(a) principal: Zinni,María A.
Data de Publicação: 2004
Outros Autores: Aljinovic,Ernesto M., Iglesias,Luis E., Iribarren,Adolfo M.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300022
Resumo: The preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design. At 25 ºC better experimental conditions allowed an increase in the yield of 2 from 80% to 96%. In addition to the yield improvement, the volume reaction could be diminished in a factor of 5 and the reaction time significantly shortened.
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spelling Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodologyenzymatic alcoholysisexperimental designlipasesnucleosidesThe preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design. At 25 ºC better experimental conditions allowed an increase in the yield of 2 from 80% to 96%. In addition to the yield improvement, the volume reaction could be diminished in a factor of 5 and the reaction time significantly shortened.Sociedade Brasileira de Química2004-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300022Química Nova v.27 n.3 2004reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422004000300022info:eu-repo/semantics/openAccessZinni,María A.Aljinovic,Ernesto M.Iglesias,Luis E.Iribarren,Adolfo M.eng2004-07-13T00:00:00Zoai:scielo:S0100-40422004000300022Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2004-07-13T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
title Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
spellingShingle Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
Zinni,María A.
enzymatic alcoholysis
experimental design
lipases
nucleosides
title_short Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
title_full Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
title_fullStr Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
title_full_unstemmed Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
title_sort Optimisation of the lipase-catalysed preparation of a nucleoside prodrug model using an experimental design methodology
author Zinni,María A.
author_facet Zinni,María A.
Aljinovic,Ernesto M.
Iglesias,Luis E.
Iribarren,Adolfo M.
author_role author
author2 Aljinovic,Ernesto M.
Iglesias,Luis E.
Iribarren,Adolfo M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Zinni,María A.
Aljinovic,Ernesto M.
Iglesias,Luis E.
Iribarren,Adolfo M.
dc.subject.por.fl_str_mv enzymatic alcoholysis
experimental design
lipases
nucleosides
topic enzymatic alcoholysis
experimental design
lipases
nucleosides
description The preparation of 2', 3'-di-O-hexanoyluridine (2) by a Candida antarctica B lipase-catalysed alcoholysis of 2', 3', 5'-tri-O-hexanoyluridine (1) was optimised using an experimental design. At 25 ºC better experimental conditions allowed an increase in the yield of 2 from 80% to 96%. In addition to the yield improvement, the volume reaction could be diminished in a factor of 5 and the reaction time significantly shortened.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000300022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422004000300022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.27 n.3 2004
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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