Atividade antiproliferativa de Sloanea garckeana K. Schum.

Detalhes bibliográficos
Autor(a) principal: Romero,Adriano Lopes
Data de Publicação: 2008
Outros Autores: Fontana,Álvaro, Silva,Cleuza Conceição da, Souza,Maria Conceição de, Carvalho,João Ernesto de, Faria,Emiret O., Kato,Lucilia, Oliveira,Cecília M. A. de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000600016
Resumo: The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.
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spelling Atividade antiproliferativa de Sloanea garckeana K. Schum.Sloanea garkeanaElaeocarpaceae3-O-methyl ellagic acid-4'-O-α-L-rhamnosideThe crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000600016Química Nova v.31 n.6 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000600016info:eu-repo/semantics/openAccessRomero,Adriano LopesFontana,ÁlvaroSilva,Cleuza Conceição daSouza,Maria Conceição deCarvalho,João Ernesto deFaria,Emiret O.Kato,LuciliaOliveira,Cecília M. A. depor2008-10-10T00:00:00Zoai:scielo:S0100-40422008000600016Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-10-10T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Atividade antiproliferativa de Sloanea garckeana K. Schum.
title Atividade antiproliferativa de Sloanea garckeana K. Schum.
spellingShingle Atividade antiproliferativa de Sloanea garckeana K. Schum.
Romero,Adriano Lopes
Sloanea garkeana
Elaeocarpaceae
3-O-methyl ellagic acid-4'-O-α-L-rhamnoside
title_short Atividade antiproliferativa de Sloanea garckeana K. Schum.
title_full Atividade antiproliferativa de Sloanea garckeana K. Schum.
title_fullStr Atividade antiproliferativa de Sloanea garckeana K. Schum.
title_full_unstemmed Atividade antiproliferativa de Sloanea garckeana K. Schum.
title_sort Atividade antiproliferativa de Sloanea garckeana K. Schum.
author Romero,Adriano Lopes
author_facet Romero,Adriano Lopes
Fontana,Álvaro
Silva,Cleuza Conceição da
Souza,Maria Conceição de
Carvalho,João Ernesto de
Faria,Emiret O.
Kato,Lucilia
Oliveira,Cecília M. A. de
author_role author
author2 Fontana,Álvaro
Silva,Cleuza Conceição da
Souza,Maria Conceição de
Carvalho,João Ernesto de
Faria,Emiret O.
Kato,Lucilia
Oliveira,Cecília M. A. de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Romero,Adriano Lopes
Fontana,Álvaro
Silva,Cleuza Conceição da
Souza,Maria Conceição de
Carvalho,João Ernesto de
Faria,Emiret O.
Kato,Lucilia
Oliveira,Cecília M. A. de
dc.subject.por.fl_str_mv Sloanea garkeana
Elaeocarpaceae
3-O-methyl ellagic acid-4'-O-α-L-rhamnoside
topic Sloanea garkeana
Elaeocarpaceae
3-O-methyl ellagic acid-4'-O-α-L-rhamnoside
description The crude methanol extract and hexane, ethyl acetate, chloroform and methanol fractions from leaves of S. garckeana were examined in vitro for their antiproliferative activity on MCF-7, NCI-ADR, NCI-460, UACC-62, 786-0, OVCAR-03, PCO-3 and HT-29 human cancer cell lines. Among the assayed fractions, the ethyl acetate fraction showed to be cytotoxic against 786-0, UACC-62, OVCAR-03 and NCI-ADR cell lines with IC50 values of 12 µg/mL, 42 µg/mL, 53 µg/mL and 51 µg/mL, respectively. Through fractionation and isolation procedures compound (1) was obtained from the EtOAc fraction and its structure was elucidated by spectral techniques.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000600016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000600016
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000600016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.6 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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