Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules

Detalhes bibliográficos
Autor(a) principal: Santoro,Maria Inês R. M.
Data de Publicação: 2006
Outros Autores: Taborianski,Andréia M., Singh,Anil Kumar, Kedor-Hackmann,Erika R. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000200012
Resumo: Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.
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spelling Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsulesliquid chromatographyantiviral drugsstability studiesZidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.Sociedade Brasileira de Química2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000200012Química Nova v.29 n.2 2006reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422006000200012info:eu-repo/semantics/openAccessSantoro,Maria Inês R. M.Taborianski,Andréia M.Singh,Anil KumarKedor-Hackmann,Erika R. M.eng2006-04-03T00:00:00Zoai:scielo:S0100-40422006000200012Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2006-04-03T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
title Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
spellingShingle Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
Santoro,Maria Inês R. M.
liquid chromatography
antiviral drugs
stability studies
title_short Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
title_full Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
title_fullStr Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
title_full_unstemmed Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
title_sort Stability-indicating methods for quantitative determination of zidovudine and stavudine in capsules
author Santoro,Maria Inês R. M.
author_facet Santoro,Maria Inês R. M.
Taborianski,Andréia M.
Singh,Anil Kumar
Kedor-Hackmann,Erika R. M.
author_role author
author2 Taborianski,Andréia M.
Singh,Anil Kumar
Kedor-Hackmann,Erika R. M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Santoro,Maria Inês R. M.
Taborianski,Andréia M.
Singh,Anil Kumar
Kedor-Hackmann,Erika R. M.
dc.subject.por.fl_str_mv liquid chromatography
antiviral drugs
stability studies
topic liquid chromatography
antiviral drugs
stability studies
description Zidovudine (AZT) and stavudine (D4T) are nucleoside reverse transcriptase inhibitors extensively used in human immunodeficiency virus (HIV) infected patients. In order to evaluate the quality of these drugs, two stability indicating HPLC methods were developed. The validated methods were applied in quantitative determination of AZT, D4T and their induced degradation products in capsule preparations. The stability studies were conducted at controlled temperature and relative humidity conditions based on the International Conference on Harmonization stability studies protocol for Zone IV areas. Easy sample preparation and low-cost make these methods especially useful for quality control and stability studies of AZT and D4T in drug products.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000200012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422006000200012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.29 n.2 2006
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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