Antimoniais empregados no tratamento da leishmaniose: estado da arte

Detalhes bibliográficos
Autor(a) principal: Rath,Susanne
Data de Publicação: 2003
Outros Autores: Trivelin,Luciano Augusto, Imbrunito,Talitha Rebecca, Tomazela,Daniela Maria, Jesús,Marcelo Nunes de, Marzal,Percy Calvo, Andrade Junior,Heitor Franco de, Tempone,André Gustavo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018
Resumo: Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified.
id SBQ-3_892a85b4d543ec81598fb904c1265a08
oai_identifier_str oai:scielo:S0100-40422003000400018
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Antimoniais empregados no tratamento da leishmaniose: estado da arteantimonyleishmaniasistherapyAntimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified.Sociedade Brasileira de Química2003-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018Química Nova v.26 n.4 2003reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422003000400018info:eu-repo/semantics/openAccessRath,SusanneTrivelin,Luciano AugustoImbrunito,Talitha RebeccaTomazela,Daniela MariaJesús,Marcelo Nunes deMarzal,Percy CalvoAndrade Junior,Heitor Franco deTempone,André Gustavopor2003-08-04T00:00:00Zoai:scielo:S0100-40422003000400018Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2003-08-04T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Antimoniais empregados no tratamento da leishmaniose: estado da arte
title Antimoniais empregados no tratamento da leishmaniose: estado da arte
spellingShingle Antimoniais empregados no tratamento da leishmaniose: estado da arte
Rath,Susanne
antimony
leishmaniasis
therapy
title_short Antimoniais empregados no tratamento da leishmaniose: estado da arte
title_full Antimoniais empregados no tratamento da leishmaniose: estado da arte
title_fullStr Antimoniais empregados no tratamento da leishmaniose: estado da arte
title_full_unstemmed Antimoniais empregados no tratamento da leishmaniose: estado da arte
title_sort Antimoniais empregados no tratamento da leishmaniose: estado da arte
author Rath,Susanne
author_facet Rath,Susanne
Trivelin,Luciano Augusto
Imbrunito,Talitha Rebecca
Tomazela,Daniela Maria
Jesús,Marcelo Nunes de
Marzal,Percy Calvo
Andrade Junior,Heitor Franco de
Tempone,André Gustavo
author_role author
author2 Trivelin,Luciano Augusto
Imbrunito,Talitha Rebecca
Tomazela,Daniela Maria
Jesús,Marcelo Nunes de
Marzal,Percy Calvo
Andrade Junior,Heitor Franco de
Tempone,André Gustavo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rath,Susanne
Trivelin,Luciano Augusto
Imbrunito,Talitha Rebecca
Tomazela,Daniela Maria
Jesús,Marcelo Nunes de
Marzal,Percy Calvo
Andrade Junior,Heitor Franco de
Tempone,André Gustavo
dc.subject.por.fl_str_mv antimony
leishmaniasis
therapy
topic antimony
leishmaniasis
therapy
description Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified.
publishDate 2003
dc.date.none.fl_str_mv 2003-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422003000400018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.26 n.4 2003
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318103414177792

Registros relacionados