Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Detalhes bibliográficos
Autor(a) principal: Filippin,Fabíola Branco
Data de Publicação: 2008
Outros Autores: Souza,Liliete Canes, Maranhão,Raul Cavalcante
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024
Resumo: Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.
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spelling Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activityamphotericin Blipid nanoemulsiondelivery systemAmphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024Química Nova v.31 n.3 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000300024info:eu-repo/semantics/openAccessFilippin,Fabíola BrancoSouza,Liliete CanesMaranhão,Raul Cavalcanteeng2008-06-16T00:00:00Zoai:scielo:S0100-40422008000300024Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-06-16T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
title Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
spellingShingle Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
Filippin,Fabíola Branco
amphotericin B
lipid nanoemulsion
delivery system
title_short Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
title_full Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
title_fullStr Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
title_full_unstemmed Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
title_sort Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity
author Filippin,Fabíola Branco
author_facet Filippin,Fabíola Branco
Souza,Liliete Canes
Maranhão,Raul Cavalcante
author_role author
author2 Souza,Liliete Canes
Maranhão,Raul Cavalcante
author2_role author
author
dc.contributor.author.fl_str_mv Filippin,Fabíola Branco
Souza,Liliete Canes
Maranhão,Raul Cavalcante
dc.subject.por.fl_str_mv amphotericin B
lipid nanoemulsion
delivery system
topic amphotericin B
lipid nanoemulsion
delivery system
description Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000300024
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.3 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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