IMIDAZOL E CATÁLISE: UM PAR PERFEITO

Detalhes bibliográficos
Autor(a) principal: Silva,Valmir B.
Data de Publicação: 2021
Outros Autores: Orth,Elisa S.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000300318
Resumo: The imidazole (IMZ) ring presents several chemical properties that turns it into a versatile acid-basic/nucleophilic catalyst. The discovery of the biological properties of histidine (amino acid with IMZ ring) instigates the study of this class of compounds. It is found in nature in several enzymes such as chymotrypsin and RNAses due to these properties. This review is focused on the catalytic role of IMZ towards the cleavage of acyl and phosphate esters and is structured in the following topics: chemical properties, biological catalysis (RNAses, phosphohistidines, chymotrypsin), intermolecular and intramolecular catalytic models and polymer and nanomaterials-based catalysts. Besides we discuss some properties such as tautomerism, stability, basicity and spectroscopic behavior, correlating with its reactivity in deacylation and dephosphorylation reactions. The main reaction mechanisms and kinetics promoted by IMZ as an acid, basic and nucleophilic catalysts are explored showing some examples. In addition, the importance of IMZ in enzymatic sites and their mechanisms and further combining properties of IMZ with some materials such as (bio)polymers, graphene, and cyclodextrines are covered. In this sense, with the wide IMZ data presented here, we are evidencing the perfect match between IMZ and catalysis.
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spelling IMIDAZOL E CATÁLISE: UM PAR PERFEITOreaction mechanismsdeacylationdephoshorylationorganophosphatesenzymatic modelsThe imidazole (IMZ) ring presents several chemical properties that turns it into a versatile acid-basic/nucleophilic catalyst. The discovery of the biological properties of histidine (amino acid with IMZ ring) instigates the study of this class of compounds. It is found in nature in several enzymes such as chymotrypsin and RNAses due to these properties. This review is focused on the catalytic role of IMZ towards the cleavage of acyl and phosphate esters and is structured in the following topics: chemical properties, biological catalysis (RNAses, phosphohistidines, chymotrypsin), intermolecular and intramolecular catalytic models and polymer and nanomaterials-based catalysts. Besides we discuss some properties such as tautomerism, stability, basicity and spectroscopic behavior, correlating with its reactivity in deacylation and dephosphorylation reactions. The main reaction mechanisms and kinetics promoted by IMZ as an acid, basic and nucleophilic catalysts are explored showing some examples. In addition, the importance of IMZ in enzymatic sites and their mechanisms and further combining properties of IMZ with some materials such as (bio)polymers, graphene, and cyclodextrines are covered. In this sense, with the wide IMZ data presented here, we are evidencing the perfect match between IMZ and catalysis.Sociedade Brasileira de Química2021-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000300318Química Nova v.44 n.3 2021reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170659info:eu-repo/semantics/openAccessSilva,Valmir B.Orth,Elisa S.por2021-05-21T00:00:00Zoai:scielo:S0100-40422021000300318Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2021-05-21T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv IMIDAZOL E CATÁLISE: UM PAR PERFEITO
title IMIDAZOL E CATÁLISE: UM PAR PERFEITO
spellingShingle IMIDAZOL E CATÁLISE: UM PAR PERFEITO
Silva,Valmir B.
reaction mechanisms
deacylation
dephoshorylation
organophosphates
enzymatic models
title_short IMIDAZOL E CATÁLISE: UM PAR PERFEITO
title_full IMIDAZOL E CATÁLISE: UM PAR PERFEITO
title_fullStr IMIDAZOL E CATÁLISE: UM PAR PERFEITO
title_full_unstemmed IMIDAZOL E CATÁLISE: UM PAR PERFEITO
title_sort IMIDAZOL E CATÁLISE: UM PAR PERFEITO
author Silva,Valmir B.
author_facet Silva,Valmir B.
Orth,Elisa S.
author_role author
author2 Orth,Elisa S.
author2_role author
dc.contributor.author.fl_str_mv Silva,Valmir B.
Orth,Elisa S.
dc.subject.por.fl_str_mv reaction mechanisms
deacylation
dephoshorylation
organophosphates
enzymatic models
topic reaction mechanisms
deacylation
dephoshorylation
organophosphates
enzymatic models
description The imidazole (IMZ) ring presents several chemical properties that turns it into a versatile acid-basic/nucleophilic catalyst. The discovery of the biological properties of histidine (amino acid with IMZ ring) instigates the study of this class of compounds. It is found in nature in several enzymes such as chymotrypsin and RNAses due to these properties. This review is focused on the catalytic role of IMZ towards the cleavage of acyl and phosphate esters and is structured in the following topics: chemical properties, biological catalysis (RNAses, phosphohistidines, chymotrypsin), intermolecular and intramolecular catalytic models and polymer and nanomaterials-based catalysts. Besides we discuss some properties such as tautomerism, stability, basicity and spectroscopic behavior, correlating with its reactivity in deacylation and dephosphorylation reactions. The main reaction mechanisms and kinetics promoted by IMZ as an acid, basic and nucleophilic catalysts are explored showing some examples. In addition, the importance of IMZ in enzymatic sites and their mechanisms and further combining properties of IMZ with some materials such as (bio)polymers, graphene, and cyclodextrines are covered. In this sense, with the wide IMZ data presented here, we are evidencing the perfect match between IMZ and catalysis.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000300318
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422021000300318
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170659
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.44 n.3 2021
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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