Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata

• Autor(a) principal: Rodrigues,Vanessa G.
• Data de Publicação: 2012
• Outros Autores: Duarte,Lucienir P., Silva,Grácia D. F., Silva,Fernando C., Góes,Jefferson V., Takahashi,Jacqueline A., Pimenta,Lúcia P. S., Vieira Filho,Sidney A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Química Nova (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000700017
• topic: Maytenus imbricata; Celastraceae; pentacyclic triterpenes

The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, ¹H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.