Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries

Detalhes bibliográficos
Autor(a) principal: Costa,Vicente Carlos de O.
Data de Publicação: 2012
Outros Autores: Tavares,Josean F., Queiroga,Cinthia S., Castello-Branco,Marianna V. S., Diniz,Margareth F. F. Melo, Lima,Carolina Uchôa G. B. de, Santos,Bárbara Viviana de O., Pita,João Carlos L. R., Silva,Marcelo Sobral da, Sette,Ivana Maria Fechine
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100025
Resumo: The phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named α-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol, β-caryophyllene and 4β,10α-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were determined by analysis of IR, MS and NMR data, as well as by comparison with literature data. The crude extract of R. leptopetala leaves demonstrated a weak cytotoxicity on sarcoma 180 cells with an IC50 of 512.3 µg/mL. However, the in vivo results showed that the extract exhibited a significant dose-dependent tumor growth reduction.
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spelling Constituintes químicos das folhas de Rollinia leptopetala R. E. FriesRollinia leptopetalaα-terpinyl caffeatealkaloidsThe phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named α-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol, β-caryophyllene and 4β,10α-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were determined by analysis of IR, MS and NMR data, as well as by comparison with literature data. The crude extract of R. leptopetala leaves demonstrated a weak cytotoxicity on sarcoma 180 cells with an IC50 of 512.3 µg/mL. However, the in vivo results showed that the extract exhibited a significant dose-dependent tumor growth reduction.Sociedade Brasileira de Química2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100025Química Nova v.35 n.1 2012reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422012000100025info:eu-repo/semantics/openAccessCosta,Vicente Carlos de O.Tavares,Josean F.Queiroga,Cinthia S.Castello-Branco,Marianna V. S.Diniz,Margareth F. F. MeloLima,Carolina Uchôa G. B. deSantos,Bárbara Viviana de O.Pita,João Carlos L. R.Silva,Marcelo Sobral daSette,Ivana Maria Fechinepor2012-02-27T00:00:00Zoai:scielo:S0100-40422012000100025Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2012-02-27T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
title Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
spellingShingle Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
Costa,Vicente Carlos de O.
Rollinia leptopetala
α-terpinyl caffeate
alkaloids
title_short Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
title_full Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
title_fullStr Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
title_full_unstemmed Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
title_sort Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
author Costa,Vicente Carlos de O.
author_facet Costa,Vicente Carlos de O.
Tavares,Josean F.
Queiroga,Cinthia S.
Castello-Branco,Marianna V. S.
Diniz,Margareth F. F. Melo
Lima,Carolina Uchôa G. B. de
Santos,Bárbara Viviana de O.
Pita,João Carlos L. R.
Silva,Marcelo Sobral da
Sette,Ivana Maria Fechine
author_role author
author2 Tavares,Josean F.
Queiroga,Cinthia S.
Castello-Branco,Marianna V. S.
Diniz,Margareth F. F. Melo
Lima,Carolina Uchôa G. B. de
Santos,Bárbara Viviana de O.
Pita,João Carlos L. R.
Silva,Marcelo Sobral da
Sette,Ivana Maria Fechine
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa,Vicente Carlos de O.
Tavares,Josean F.
Queiroga,Cinthia S.
Castello-Branco,Marianna V. S.
Diniz,Margareth F. F. Melo
Lima,Carolina Uchôa G. B. de
Santos,Bárbara Viviana de O.
Pita,João Carlos L. R.
Silva,Marcelo Sobral da
Sette,Ivana Maria Fechine
dc.subject.por.fl_str_mv Rollinia leptopetala
α-terpinyl caffeate
alkaloids
topic Rollinia leptopetala
α-terpinyl caffeate
alkaloids
description The phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named α-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol, β-caryophyllene and 4β,10α-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were determined by analysis of IR, MS and NMR data, as well as by comparison with literature data. The crude extract of R. leptopetala leaves demonstrated a weak cytotoxicity on sarcoma 180 cells with an IC50 of 512.3 µg/mL. However, the in vivo results showed that the extract exhibited a significant dose-dependent tumor growth reduction.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100025
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100025
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422012000100025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.35 n.1 2012
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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