Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas

Detalhes bibliográficos
Autor(a) principal: Fernandes,Christian
Data de Publicação: 2005
Outros Autores: Leite,Rodrigo Souza, Lanças,Fernando Mauro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200019
Resumo: Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Various synthetic routes to prepare different types of bisphosphonates have been described, with distinct potency and pharmacological activity. A number of analytical techniques are currently being used to analyze these drugs; among these, the high performance liquid chromatography (HPLC), with different systems of detection, is worth highlighting. However, the development of more sensitive methods is still necessary, once they are essential for bioavailability and bioequivalence studies. This paper reports the major synthesis routes, chemical analysis methodologies and pharmacological applications of bisphosphonates.
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spelling Bisfosfonatos: síntese, análises químicas e aplicações farmacológicasbisphosphonatesbone diseaseshigh performance liquid chromatographyBisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Various synthetic routes to prepare different types of bisphosphonates have been described, with distinct potency and pharmacological activity. A number of analytical techniques are currently being used to analyze these drugs; among these, the high performance liquid chromatography (HPLC), with different systems of detection, is worth highlighting. However, the development of more sensitive methods is still necessary, once they are essential for bioavailability and bioequivalence studies. This paper reports the major synthesis routes, chemical analysis methodologies and pharmacological applications of bisphosphonates.Sociedade Brasileira de Química2005-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200019Química Nova v.28 n.2 2005reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422005000200019info:eu-repo/semantics/openAccessFernandes,ChristianLeite,Rodrigo SouzaLanças,Fernando Mauropor2005-05-04T00:00:00Zoai:scielo:S0100-40422005000200019Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2005-05-04T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
title Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
spellingShingle Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
Fernandes,Christian
bisphosphonates
bone diseases
high performance liquid chromatography
title_short Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
title_full Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
title_fullStr Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
title_full_unstemmed Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
title_sort Bisfosfonatos: síntese, análises químicas e aplicações farmacológicas
author Fernandes,Christian
author_facet Fernandes,Christian
Leite,Rodrigo Souza
Lanças,Fernando Mauro
author_role author
author2 Leite,Rodrigo Souza
Lanças,Fernando Mauro
author2_role author
author
dc.contributor.author.fl_str_mv Fernandes,Christian
Leite,Rodrigo Souza
Lanças,Fernando Mauro
dc.subject.por.fl_str_mv bisphosphonates
bone diseases
high performance liquid chromatography
topic bisphosphonates
bone diseases
high performance liquid chromatography
description Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Various synthetic routes to prepare different types of bisphosphonates have been described, with distinct potency and pharmacological activity. A number of analytical techniques are currently being used to analyze these drugs; among these, the high performance liquid chromatography (HPLC), with different systems of detection, is worth highlighting. However, the development of more sensitive methods is still necessary, once they are essential for bioavailability and bioequivalence studies. This paper reports the major synthesis routes, chemical analysis methodologies and pharmacological applications of bisphosphonates.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200019
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422005000200019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.28 n.2 2005
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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