SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa

Detalhes bibliográficos
Autor(a) principal: Sousa,Thuanny M. de
Data de Publicação: 2020
Outros Autores: Penha,Dayana P. S., Pontes,Daniel de L., Pontes,Ana C. F. de B., Silva,Francisco O. N. da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000200194
Resumo: The compounds nitrosyl cis-[Ru(bpy)(phen)TU(NO)](PF6)3 (compound 1) and cis-[Ru(bpy)(phen)(4-N-Imd)(NO)](PF6)3 (compound 2) (bpy = 2,2’-bipyridine, phen = 1,10’-phenanthroline, TU = thiourea and 4-N-Imd = 4-nitroimidazole) were synthesized and characterized by UV-visible, infrared spectroscopies and electrochemical techniques. In the study of the reactivity it was possible to verify the nitric oxide labilization by square wave voltammetry and a photochemical upon blue light irradiation. This feature is very important for a potential application in phototherapy. Additionally, the antibacterial activity of the nitrosyl complexes was tested against gram-negative bacteria Pseudomonas aeruginosa. Thus, it has been observed that the complexes are capable of inhibiting the growth of such microorganisms.
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spelling SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosarutheniumnitrix oxidePseudomonas aeruginosaThe compounds nitrosyl cis-[Ru(bpy)(phen)TU(NO)](PF6)3 (compound 1) and cis-[Ru(bpy)(phen)(4-N-Imd)(NO)](PF6)3 (compound 2) (bpy = 2,2’-bipyridine, phen = 1,10’-phenanthroline, TU = thiourea and 4-N-Imd = 4-nitroimidazole) were synthesized and characterized by UV-visible, infrared spectroscopies and electrochemical techniques. In the study of the reactivity it was possible to verify the nitric oxide labilization by square wave voltammetry and a photochemical upon blue light irradiation. This feature is very important for a potential application in phototherapy. Additionally, the antibacterial activity of the nitrosyl complexes was tested against gram-negative bacteria Pseudomonas aeruginosa. Thus, it has been observed that the complexes are capable of inhibiting the growth of such microorganisms.Sociedade Brasileira de Química2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000200194Química Nova v.43 n.2 2020reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0100-4042.20170476info:eu-repo/semantics/openAccessSousa,Thuanny M. dePenha,Dayana P. S.Pontes,Daniel de L.Pontes,Ana C. F. de B.Silva,Francisco O. N. dapor2020-05-12T00:00:00Zoai:scielo:S0100-40422020000200194Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2020-05-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
title SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
spellingShingle SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
Sousa,Thuanny M. de
ruthenium
nitrix oxide
Pseudomonas aeruginosa
title_short SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
title_full SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
title_fullStr SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
title_full_unstemmed SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
title_sort SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa
author Sousa,Thuanny M. de
author_facet Sousa,Thuanny M. de
Penha,Dayana P. S.
Pontes,Daniel de L.
Pontes,Ana C. F. de B.
Silva,Francisco O. N. da
author_role author
author2 Penha,Dayana P. S.
Pontes,Daniel de L.
Pontes,Ana C. F. de B.
Silva,Francisco O. N. da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Sousa,Thuanny M. de
Penha,Dayana P. S.
Pontes,Daniel de L.
Pontes,Ana C. F. de B.
Silva,Francisco O. N. da
dc.subject.por.fl_str_mv ruthenium
nitrix oxide
Pseudomonas aeruginosa
topic ruthenium
nitrix oxide
Pseudomonas aeruginosa
description The compounds nitrosyl cis-[Ru(bpy)(phen)TU(NO)](PF6)3 (compound 1) and cis-[Ru(bpy)(phen)(4-N-Imd)(NO)](PF6)3 (compound 2) (bpy = 2,2’-bipyridine, phen = 1,10’-phenanthroline, TU = thiourea and 4-N-Imd = 4-nitroimidazole) were synthesized and characterized by UV-visible, infrared spectroscopies and electrochemical techniques. In the study of the reactivity it was possible to verify the nitric oxide labilization by square wave voltammetry and a photochemical upon blue light irradiation. This feature is very important for a potential application in phototherapy. Additionally, the antibacterial activity of the nitrosyl complexes was tested against gram-negative bacteria Pseudomonas aeruginosa. Thus, it has been observed that the complexes are capable of inhibiting the growth of such microorganisms.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000200194
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000200194
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.21577/0100-4042.20170476
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.43 n.2 2020
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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