Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400021 |
Resumo: | Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors. |
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Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de AlzheimerAlzheimer's diseaseacetylcholinesterasenatural productsAlzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors.Sociedade Brasileira de Química2004-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400021Química Nova v.27 n.4 2004reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422004000400021info:eu-repo/semantics/openAccessViegas Junior,CláudioBolzani,Vanderlan da SilvaFurlan,MaysaFraga,Carlos Alberto ManssourBarreiro,Eliezer J.por2004-07-31T00:00:00Zoai:scielo:S0100-40422004000400021Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2004-07-31T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
title |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
spellingShingle |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer Viegas Junior,Cláudio Alzheimer's disease acetylcholinesterase natural products |
title_short |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
title_full |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
title_fullStr |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
title_full_unstemmed |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
title_sort |
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer |
author |
Viegas Junior,Cláudio |
author_facet |
Viegas Junior,Cláudio Bolzani,Vanderlan da Silva Furlan,Maysa Fraga,Carlos Alberto Manssour Barreiro,Eliezer J. |
author_role |
author |
author2 |
Bolzani,Vanderlan da Silva Furlan,Maysa Fraga,Carlos Alberto Manssour Barreiro,Eliezer J. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Viegas Junior,Cláudio Bolzani,Vanderlan da Silva Furlan,Maysa Fraga,Carlos Alberto Manssour Barreiro,Eliezer J. |
dc.subject.por.fl_str_mv |
Alzheimer's disease acetylcholinesterase natural products |
topic |
Alzheimer's disease acetylcholinesterase natural products |
description |
Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400021 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422004000400021 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422004000400021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.27 n.4 2004 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318103879745536 |