Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

Detalhes bibliográficos
Autor(a) principal: Chandra,Bala Sekaran
Data de Publicação: 2011
Outros Autores: Bhogela,Siva Santhosh, Shaik,Manjusha, Vadlamudi,Chaitanya Sravanthi, Chappa,Meghana, Maddirala,Naga Sirisha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600026
Resumo: Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL-1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.
id SBQ-3_be12074baa81712bb0be977c08b3f07c
oai_identifier_str oai:scielo:S0100-40422011000600026
network_acronym_str SBQ-3
network_name_str Química Nova (Online)
repository_id_str
spelling Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage formsmesalaminespectrophotometric analysisvalidationThree simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL-1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600026Química Nova v.34 n.6 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011000600026info:eu-repo/semantics/openAccessChandra,Bala SekaranBhogela,Siva SanthoshShaik,ManjushaVadlamudi,Chaitanya SravanthiChappa,MeghanaMaddirala,Naga Sirishaeng2011-08-01T00:00:00Zoai:scielo:S0100-40422011000600026Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-08-01T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
title Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
spellingShingle Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
Chandra,Bala Sekaran
mesalamine
spectrophotometric analysis
validation
title_short Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
title_full Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
title_fullStr Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
title_full_unstemmed Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
title_sort Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms
author Chandra,Bala Sekaran
author_facet Chandra,Bala Sekaran
Bhogela,Siva Santhosh
Shaik,Manjusha
Vadlamudi,Chaitanya Sravanthi
Chappa,Meghana
Maddirala,Naga Sirisha
author_role author
author2 Bhogela,Siva Santhosh
Shaik,Manjusha
Vadlamudi,Chaitanya Sravanthi
Chappa,Meghana
Maddirala,Naga Sirisha
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Chandra,Bala Sekaran
Bhogela,Siva Santhosh
Shaik,Manjusha
Vadlamudi,Chaitanya Sravanthi
Chappa,Meghana
Maddirala,Naga Sirisha
dc.subject.por.fl_str_mv mesalamine
spectrophotometric analysis
validation
topic mesalamine
spectrophotometric analysis
validation
description Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL-1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000600026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422011000600026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.6 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318112332316672

Registros relacionados