Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial

Detalhes bibliográficos
Autor(a) principal: Souto,Eliana B
Data de Publicação: 2011
Outros Autores: Severino,Patrícia, Santana,Maria Helena A, Pinho,Samantha C
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011001000009
Resumo: Solid lipid nanoparticles have been extensively investigated as drug delivery systems. These colloidal systems have major advantages compared to others more traditional. Reported advantages include sustained release, ability to solubilize lipophilic drugs, increased physical and chemical stability of labile molecules, decreased unwanted side-effects showing lower toxicity, and scale up facilities. This paper aims at reviewing the traditional methods of solid lipid nanoparticles production, such as fusion-emulsification (hot and cold), solvent evaporation-emulsification and microemulsion, dealing with the main technological parameters that influence the quality properties of solid lipid nanoparticles.
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spelling Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorialsolid lipid nanoparticleproduction of methodstechnological parametersSolid lipid nanoparticles have been extensively investigated as drug delivery systems. These colloidal systems have major advantages compared to others more traditional. Reported advantages include sustained release, ability to solubilize lipophilic drugs, increased physical and chemical stability of labile molecules, decreased unwanted side-effects showing lower toxicity, and scale up facilities. This paper aims at reviewing the traditional methods of solid lipid nanoparticles production, such as fusion-emulsification (hot and cold), solvent evaporation-emulsification and microemulsion, dealing with the main technological parameters that influence the quality properties of solid lipid nanoparticles.Sociedade Brasileira de Química2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011001000009Química Nova v.34 n.10 2011reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422011001000009info:eu-repo/semantics/openAccessSouto,Eliana BSeverino,PatríciaSantana,Maria Helena APinho,Samantha Cpor2011-12-06T00:00:00Zoai:scielo:S0100-40422011001000009Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-12-06T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
title Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
spellingShingle Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
Souto,Eliana B
solid lipid nanoparticle
production of methods
technological parameters
title_short Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
title_full Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
title_fullStr Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
title_full_unstemmed Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
title_sort Nanopartículas de lipídios sólidos: métodos clássicos de produção laboratorial
author Souto,Eliana B
author_facet Souto,Eliana B
Severino,Patrícia
Santana,Maria Helena A
Pinho,Samantha C
author_role author
author2 Severino,Patrícia
Santana,Maria Helena A
Pinho,Samantha C
author2_role author
author
author
dc.contributor.author.fl_str_mv Souto,Eliana B
Severino,Patrícia
Santana,Maria Helena A
Pinho,Samantha C
dc.subject.por.fl_str_mv solid lipid nanoparticle
production of methods
technological parameters
topic solid lipid nanoparticle
production of methods
technological parameters
description Solid lipid nanoparticles have been extensively investigated as drug delivery systems. These colloidal systems have major advantages compared to others more traditional. Reported advantages include sustained release, ability to solubilize lipophilic drugs, increased physical and chemical stability of labile molecules, decreased unwanted side-effects showing lower toxicity, and scale up facilities. This paper aims at reviewing the traditional methods of solid lipid nanoparticles production, such as fusion-emulsification (hot and cold), solvent evaporation-emulsification and microemulsion, dealing with the main technological parameters that influence the quality properties of solid lipid nanoparticles.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011001000009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011001000009
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422011001000009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.34 n.10 2011
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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