CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Química Nova (Online) |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000700932 |
Resumo: | Chemical investigation of Guettarda viburnoides (leaves) led to the isolation of ursolic acid, uncaric acid, secoxyloganin, and grandifloroside, along with a mixture of quercetin-3-O-β-D-galactopyranoside and quercetin-3-O-β-D-glucopyranoside, and of β-sitosterol and stigmasterol. The structures of the isolated compounds were elucidated on the basis of their NMR data. The crude extract, ethyl acetate fraction, aqueous-methanol fraction, and grandifloroside showed significant DPPH free-radical scavenging activities with IC50 ranging from 18.92 to 26.47 µg mL-1. The topical administration of the crude extract and fractions markedly reduced the croton oil-induced mice ear edema in 67.0%-99.0%. Inhibition of tissue MPO activity was also observed, which demonstrated an anti-inflammatory effect of the G. viburnoides species. |
| id |
SBQ-3_ccad22c01a1e52c542ec3464ebe540f0 |
|---|---|
| oai_identifier_str |
oai:scielo:S0100-40422015000700932 |
| network_acronym_str |
SBQ-3 |
| network_name_str |
Química Nova (Online) |
| repository_id_str |
|
| spelling |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE)Guettarda viburnoideschemical constituentsanti-inflammatory activityantioxidant activityChemical investigation of Guettarda viburnoides (leaves) led to the isolation of ursolic acid, uncaric acid, secoxyloganin, and grandifloroside, along with a mixture of quercetin-3-O-β-D-galactopyranoside and quercetin-3-O-β-D-glucopyranoside, and of β-sitosterol and stigmasterol. The structures of the isolated compounds were elucidated on the basis of their NMR data. The crude extract, ethyl acetate fraction, aqueous-methanol fraction, and grandifloroside showed significant DPPH free-radical scavenging activities with IC50 ranging from 18.92 to 26.47 µg mL-1. The topical administration of the crude extract and fractions markedly reduced the croton oil-induced mice ear edema in 67.0%-99.0%. Inhibition of tissue MPO activity was also observed, which demonstrated an anti-inflammatory effect of the G. viburnoides species.Sociedade Brasileira de Química2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000700932Química Nova v.38 n.7 2015reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20150093info:eu-repo/semantics/openAccessNaressi,Maria AugustaManholer,Daniele DomingosAmes,Franciele QueirozBersani-Amado,Ciomar AparecidaFormagio,Anelise Samara NazariPereira,Zefa ValdivinaCosta,Willian Ferreira daBaldoqui,Debora CristinaSarragiotto,Maria Helenaeng2015-09-21T00:00:00Zoai:scielo:S0100-40422015000700932Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2015-09-21T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
| dc.title.none.fl_str_mv |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| title |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| spellingShingle |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) Naressi,Maria Augusta Guettarda viburnoides chemical constituents anti-inflammatory activity antioxidant activity |
| title_short |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| title_full |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| title_fullStr |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| title_full_unstemmed |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| title_sort |
CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE) |
| author |
Naressi,Maria Augusta |
| author_facet |
Naressi,Maria Augusta Manholer,Daniele Domingos Ames,Franciele Queiroz Bersani-Amado,Ciomar Aparecida Formagio,Anelise Samara Nazari Pereira,Zefa Valdivina Costa,Willian Ferreira da Baldoqui,Debora Cristina Sarragiotto,Maria Helena |
| author_role |
author |
| author2 |
Manholer,Daniele Domingos Ames,Franciele Queiroz Bersani-Amado,Ciomar Aparecida Formagio,Anelise Samara Nazari Pereira,Zefa Valdivina Costa,Willian Ferreira da Baldoqui,Debora Cristina Sarragiotto,Maria Helena |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Naressi,Maria Augusta Manholer,Daniele Domingos Ames,Franciele Queiroz Bersani-Amado,Ciomar Aparecida Formagio,Anelise Samara Nazari Pereira,Zefa Valdivina Costa,Willian Ferreira da Baldoqui,Debora Cristina Sarragiotto,Maria Helena |
| dc.subject.por.fl_str_mv |
Guettarda viburnoides chemical constituents anti-inflammatory activity antioxidant activity |
| topic |
Guettarda viburnoides chemical constituents anti-inflammatory activity antioxidant activity |
| description |
Chemical investigation of Guettarda viburnoides (leaves) led to the isolation of ursolic acid, uncaric acid, secoxyloganin, and grandifloroside, along with a mixture of quercetin-3-O-β-D-galactopyranoside and quercetin-3-O-β-D-glucopyranoside, and of β-sitosterol and stigmasterol. The structures of the isolated compounds were elucidated on the basis of their NMR data. The crude extract, ethyl acetate fraction, aqueous-methanol fraction, and grandifloroside showed significant DPPH free-radical scavenging activities with IC50 ranging from 18.92 to 26.47 µg mL-1. The topical administration of the crude extract and fractions markedly reduced the croton oil-induced mice ear edema in 67.0%-99.0%. Inhibition of tissue MPO activity was also observed, which demonstrated an anti-inflammatory effect of the G. viburnoides species. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-08-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000700932 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000700932 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.5935/0100-4042.20150093 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
| publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
| dc.source.none.fl_str_mv |
Química Nova v.38 n.7 2015 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| instname_str |
Sociedade Brasileira de Química (SBQ) |
| instacron_str |
SBQ |
| institution |
SBQ |
| reponame_str |
Química Nova (Online) |
| collection |
Química Nova (Online) |
| repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
| repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
| _version_ |
1750318117045665792 |