Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300026 |
Resumo: | A flow injection method for the quantitative analysis of ketoconazole in tablets, based on the reaction with iron (III) ions, is presented. Ketoconazole forms a red complex with iron ions in an acid medium, with maximum absorbance at 495 nm. The detection limit was estimated to be 1×10--4 mol L-1; the quantitation limit is about 3×10--4 mol L-1 and approximately 30 determinations can be performed in an hour. The results were compared with those obtained with a reference HPLC method. Statistical comparisons were done using the Student's t procedure and the F test. Complete agreement was found at the 0.95 significance level between the proposed flow injection and the HPLC procedures. The two methods present similar precision, i.e., for HPLC the mean relative standard deviation was ca. 1.2% and for FIA ca. 1.6%. |
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Química Nova (Online) |
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Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparationsquantitative analysisketoconazoleflow injection systemA flow injection method for the quantitative analysis of ketoconazole in tablets, based on the reaction with iron (III) ions, is presented. Ketoconazole forms a red complex with iron ions in an acid medium, with maximum absorbance at 495 nm. The detection limit was estimated to be 1×10--4 mol L-1; the quantitation limit is about 3×10--4 mol L-1 and approximately 30 determinations can be performed in an hour. The results were compared with those obtained with a reference HPLC method. Statistical comparisons were done using the Student's t procedure and the F test. Complete agreement was found at the 0.95 significance level between the proposed flow injection and the HPLC procedures. The two methods present similar precision, i.e., for HPLC the mean relative standard deviation was ca. 1.2% and for FIA ca. 1.6%.Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300026Química Nova v.33 n.3 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000300026info:eu-repo/semantics/openAccessScatolin,FelipeTubino,MatthieuVila,Marta Maria Duarte Carvalhoeng2010-04-19T00:00:00Zoai:scielo:S0100-40422010000300026Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-04-19T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
title |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
spellingShingle |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations Scatolin,Felipe quantitative analysis ketoconazole flow injection system |
title_short |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
title_full |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
title_fullStr |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
title_full_unstemmed |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
title_sort |
Flow injection green method for the quantitative analysis of ketoconazole in pharmaceutical preparations |
author |
Scatolin,Felipe |
author_facet |
Scatolin,Felipe Tubino,Matthieu Vila,Marta Maria Duarte Carvalho |
author_role |
author |
author2 |
Tubino,Matthieu Vila,Marta Maria Duarte Carvalho |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Scatolin,Felipe Tubino,Matthieu Vila,Marta Maria Duarte Carvalho |
dc.subject.por.fl_str_mv |
quantitative analysis ketoconazole flow injection system |
topic |
quantitative analysis ketoconazole flow injection system |
description |
A flow injection method for the quantitative analysis of ketoconazole in tablets, based on the reaction with iron (III) ions, is presented. Ketoconazole forms a red complex with iron ions in an acid medium, with maximum absorbance at 495 nm. The detection limit was estimated to be 1×10--4 mol L-1; the quantitation limit is about 3×10--4 mol L-1 and approximately 30 determinations can be performed in an hour. The results were compared with those obtained with a reference HPLC method. Statistical comparisons were done using the Student's t procedure and the F test. Complete agreement was found at the 0.95 significance level between the proposed flow injection and the HPLC procedures. The two methods present similar precision, i.e., for HPLC the mean relative standard deviation was ca. 1.2% and for FIA ca. 1.6%. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300026 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000300026 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-40422010000300026 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.33 n.3 2010 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318110354702336 |