Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS

Detalhes bibliográficos
Autor(a) principal: Gaffney,Vanessa de Jesus
Data de Publicação: 2014
Outros Autores: Cardoso,Vitor Vale, Rodrigues,Alexandre, Ferreira,Elisabete, Benoliel,Maria João, Almeida,Cristina M. M.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100023
Resumo: A method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy. The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively. Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system. Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.
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spelling Análise de fármacos em águas por SPE-UPLC-ESI-MS/MSwaterpharmaceutical compoundsUPLC-MS/MSA method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy. The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively. Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system. Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.Sociedade Brasileira de Química2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100023Química Nova v.37 n.1 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422014000100023info:eu-repo/semantics/openAccessGaffney,Vanessa de JesusCardoso,Vitor ValeRodrigues,AlexandreFerreira,ElisabeteBenoliel,Maria JoãoAlmeida,Cristina M. M.por2014-02-18T00:00:00Zoai:scielo:S0100-40422014000100023Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-02-18T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
title Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
spellingShingle Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
Gaffney,Vanessa de Jesus
water
pharmaceutical compounds
UPLC-MS/MS
title_short Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
title_full Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
title_fullStr Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
title_full_unstemmed Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
title_sort Análise de fármacos em águas por SPE-UPLC-ESI-MS/MS
author Gaffney,Vanessa de Jesus
author_facet Gaffney,Vanessa de Jesus
Cardoso,Vitor Vale
Rodrigues,Alexandre
Ferreira,Elisabete
Benoliel,Maria João
Almeida,Cristina M. M.
author_role author
author2 Cardoso,Vitor Vale
Rodrigues,Alexandre
Ferreira,Elisabete
Benoliel,Maria João
Almeida,Cristina M. M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gaffney,Vanessa de Jesus
Cardoso,Vitor Vale
Rodrigues,Alexandre
Ferreira,Elisabete
Benoliel,Maria João
Almeida,Cristina M. M.
dc.subject.por.fl_str_mv water
pharmaceutical compounds
UPLC-MS/MS
topic water
pharmaceutical compounds
UPLC-MS/MS
description A method was developed for the analysis of 31 pharmaceutical compounds in Lisbon's drinking water system, using solid-phase extraction (SPE) and ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS). The method was validated through estimation of the linearity range, method detection and quantification limits, matrix effects, precision and accuracy. The method detection and quantification limit ranges were 0.009-10 and 0.03-33 ng/L, respectively. Analytes were quantified in water samples collected from the EPAL (Empresa Portuguesa das Águas Livres S.A.) supply system. Carbamazepine, atenolol, sulfadiazine, sulfamethazine, sulfapyridine, sulfamethoxazole, acetaminophen, caffeine and erythromycin were quantified in the analysed samples.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000100023
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422014000100023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.37 n.1 2014
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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