Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.

Detalhes bibliográficos
Autor(a) principal: Messias,Karina Louise S.
Data de Publicação: 2008
Outros Autores: Campos-Buzzi,Fátima de, Fischer,Luiz G. O., Malheiros,Ângela, Delle Monache,Franco, Cechinel Filho,Valdir
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700029
Resumo: This paper describes the isolation of five phytoconstituents from Marlierea tomentosa. The triterpenes α-amyrin (1) and β-amyrin (2), and the flavonoids quercitrin (3) and isoquercetin (4), were isolated from the leaves. The branches afforded the triterpene arjunolic acid (5). The antinociceptive activity of crude extract, fractions and compound 5 were tested using the writhing and formalin tests in mice. The crude extract, some fractions, particularly dichloromethane and butanol (leaves), ethyl acetate (branches) and arjunolic acid (5) (81.2% inhibition) were more active against the writhing test than the two reference drugs, acetylsalicylic acid and indomethacin.
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spelling Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.Marlierea tomentosaanalgesic activitytriterpenesThis paper describes the isolation of five phytoconstituents from Marlierea tomentosa. The triterpenes α-amyrin (1) and β-amyrin (2), and the flavonoids quercitrin (3) and isoquercetin (4), were isolated from the leaves. The branches afforded the triterpene arjunolic acid (5). The antinociceptive activity of crude extract, fractions and compound 5 were tested using the writhing and formalin tests in mice. The crude extract, some fractions, particularly dichloromethane and butanol (leaves), ethyl acetate (branches) and arjunolic acid (5) (81.2% inhibition) were more active against the writhing test than the two reference drugs, acetylsalicylic acid and indomethacin.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700029Química Nova v.31 n.7 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000700029info:eu-repo/semantics/openAccessMessias,Karina Louise S.Campos-Buzzi,Fátima deFischer,Luiz G. O.Malheiros,ÂngelaDelle Monache,FrancoCechinel Filho,Valdireng2008-12-09T00:00:00Zoai:scielo:S0100-40422008000700029Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-12-09T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
title Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
spellingShingle Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
Messias,Karina Louise S.
Marlierea tomentosa
analgesic activity
triterpenes
title_short Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
title_full Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
title_fullStr Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
title_full_unstemmed Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
title_sort Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.
author Messias,Karina Louise S.
author_facet Messias,Karina Louise S.
Campos-Buzzi,Fátima de
Fischer,Luiz G. O.
Malheiros,Ângela
Delle Monache,Franco
Cechinel Filho,Valdir
author_role author
author2 Campos-Buzzi,Fátima de
Fischer,Luiz G. O.
Malheiros,Ângela
Delle Monache,Franco
Cechinel Filho,Valdir
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Messias,Karina Louise S.
Campos-Buzzi,Fátima de
Fischer,Luiz G. O.
Malheiros,Ângela
Delle Monache,Franco
Cechinel Filho,Valdir
dc.subject.por.fl_str_mv Marlierea tomentosa
analgesic activity
triterpenes
topic Marlierea tomentosa
analgesic activity
triterpenes
description This paper describes the isolation of five phytoconstituents from Marlierea tomentosa. The triterpenes α-amyrin (1) and β-amyrin (2), and the flavonoids quercitrin (3) and isoquercetin (4), were isolated from the leaves. The branches afforded the triterpene arjunolic acid (5). The antinociceptive activity of crude extract, fractions and compound 5 were tested using the writhing and formalin tests in mice. The crude extract, some fractions, particularly dichloromethane and butanol (leaves), ethyl acetate (branches) and arjunolic acid (5) (81.2% inhibition) were more active against the writhing test than the two reference drugs, acetylsalicylic acid and indomethacin.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700029
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700029
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000700029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.7 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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