Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid

Detalhes bibliográficos
Autor(a) principal: Funari,Sérgio S.
Data de Publicação: 2009
Outros Autores: Rapp,Gert, Richter,Frank
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400015
Resumo: The product of catalytic activity of the enzyme phospholipase A2, which resembles the core unit of animal toxins, on phospholipids is a 1:1 mixture of lysolipid and fatty acid. This mixture was studied by time-resolved simultaneous small- and wide angle x-ray diffraction over the temperature range from 23 to 53.5ºC. An unusually large lamellar structure was observed, with d = 11 nm, contradicting the complex functional dimer model between lysolipid and fatty acid. It can be explained by formation of a "double-bilayer", a new phase consisting of two different bilayers, one formed by lysophospholipid and other by fatty acid, bound together by head group interactions. Its strucutre was confirmed by simulations of the X-ray scattering pattern.
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spelling Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acidPLA2lipid bilayerX-raysThe product of catalytic activity of the enzyme phospholipase A2, which resembles the core unit of animal toxins, on phospholipids is a 1:1 mixture of lysolipid and fatty acid. This mixture was studied by time-resolved simultaneous small- and wide angle x-ray diffraction over the temperature range from 23 to 53.5ºC. An unusually large lamellar structure was observed, with d = 11 nm, contradicting the complex functional dimer model between lysolipid and fatty acid. It can be explained by formation of a "double-bilayer", a new phase consisting of two different bilayers, one formed by lysophospholipid and other by fatty acid, bound together by head group interactions. Its strucutre was confirmed by simulations of the X-ray scattering pattern.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400015Química Nova v.32 n.4 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000400015info:eu-repo/semantics/openAccessFunari,Sérgio S.Rapp,GertRichter,Frankeng2009-06-22T00:00:00Zoai:scielo:S0100-40422009000400015Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-06-22T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
title Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
spellingShingle Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
Funari,Sérgio S.
PLA2
lipid bilayer
X-rays
title_short Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
title_full Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
title_fullStr Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
title_full_unstemmed Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
title_sort Double-bilayer: a new phase formed by lysophospholipids and the corresponding fatty acid
author Funari,Sérgio S.
author_facet Funari,Sérgio S.
Rapp,Gert
Richter,Frank
author_role author
author2 Rapp,Gert
Richter,Frank
author2_role author
author
dc.contributor.author.fl_str_mv Funari,Sérgio S.
Rapp,Gert
Richter,Frank
dc.subject.por.fl_str_mv PLA2
lipid bilayer
X-rays
topic PLA2
lipid bilayer
X-rays
description The product of catalytic activity of the enzyme phospholipase A2, which resembles the core unit of animal toxins, on phospholipids is a 1:1 mixture of lysolipid and fatty acid. This mixture was studied by time-resolved simultaneous small- and wide angle x-ray diffraction over the temperature range from 23 to 53.5ºC. An unusually large lamellar structure was observed, with d = 11 nm, contradicting the complex functional dimer model between lysolipid and fatty acid. It can be explained by formation of a "double-bilayer", a new phase consisting of two different bilayers, one formed by lysophospholipid and other by fatty acid, bound together by head group interactions. Its strucutre was confirmed by simulations of the X-ray scattering pattern.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000400015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000400015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.4 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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