Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo

Detalhes bibliográficos
Autor(a) principal: Barreiro,Eliezer J.
Data de Publicação: 2002
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018
Resumo: In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH) class, is also reported herein.
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spelling Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativonew cardiotonic derivativebioactive N-acylhydrazone compoundLASSBio-294In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH) class, is also reported herein.Sociedade Brasileira de Química2002-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018Química Nova v.25 n.6b 2002reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422002000700018info:eu-repo/semantics/openAccessBarreiro,Eliezer J.por2002-12-12T00:00:00Zoai:scielo:S0100-40422002000700018Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2002-12-12T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
title Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
spellingShingle Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
Barreiro,Eliezer J.
new cardiotonic derivative
bioactive N-acylhydrazone compound
LASSBio-294
title_short Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
title_full Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
title_fullStr Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
title_full_unstemmed Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
title_sort Estratégia de simplificação molecular no planejamento racional de fármacos: a descoberta de novo agente cardioativo
author Barreiro,Eliezer J.
author_facet Barreiro,Eliezer J.
author_role author
dc.contributor.author.fl_str_mv Barreiro,Eliezer J.
dc.subject.por.fl_str_mv new cardiotonic derivative
bioactive N-acylhydrazone compound
LASSBio-294
topic new cardiotonic derivative
bioactive N-acylhydrazone compound
LASSBio-294
description In this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. The discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; LASSBio-294), efficiently synthesized from Brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. A brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the N-acylhydrazone (NAH) class, is also reported herein.
publishDate 2002
dc.date.none.fl_str_mv 2002-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000700018
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422002000700018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.25 n.6b 2002
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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