Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?

Detalhes bibliográficos
Autor(a) principal: Barbosa,Lívea Fujita
Data de Publicação: 2006
Outros Autores: Medeiros,Marisa H.G. de, Augusto,Ohara
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600034
Resumo: Accumulated evidence indicates that oxidative stress plays a role in neurodegenerative diseases, such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis. Here, we emphasize the results provided by the technology of genetically modified animals. Studies with transgenic and knockout mice have allowed great advances in the research of oxidative stress in general and in the central nervous system, and are pointing to potential targets for the development of new drugs and therapies to disrupt the cycle of events that lead to neuronal death. Thus, genetically modified animals are a valuable tool for the comprehension of human diseases, including neurodegenerative ones.
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spelling Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?oxidative damageneurodegenerationtransgenicknockout miceAccumulated evidence indicates that oxidative stress plays a role in neurodegenerative diseases, such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis. Here, we emphasize the results provided by the technology of genetically modified animals. Studies with transgenic and knockout mice have allowed great advances in the research of oxidative stress in general and in the central nervous system, and are pointing to potential targets for the development of new drugs and therapies to disrupt the cycle of events that lead to neuronal death. Thus, genetically modified animals are a valuable tool for the comprehension of human diseases, including neurodegenerative ones.Sociedade Brasileira de Química2006-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600034Química Nova v.29 n.6 2006reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422006000600034info:eu-repo/semantics/openAccessBarbosa,Lívea FujitaMedeiros,Marisa H.G. deAugusto,Oharapor2011-09-06T00:00:00Zoai:scielo:S0100-40422006000600034Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-09-06T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
title Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
spellingShingle Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
Barbosa,Lívea Fujita
oxidative damage
neurodegeneration
transgenic
knockout mice
title_short Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
title_full Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
title_fullStr Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
title_full_unstemmed Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
title_sort Danos oxidativos e neurodegeneração: o quê aprendemos com animais transgênicos e nocautes?
author Barbosa,Lívea Fujita
author_facet Barbosa,Lívea Fujita
Medeiros,Marisa H.G. de
Augusto,Ohara
author_role author
author2 Medeiros,Marisa H.G. de
Augusto,Ohara
author2_role author
author
dc.contributor.author.fl_str_mv Barbosa,Lívea Fujita
Medeiros,Marisa H.G. de
Augusto,Ohara
dc.subject.por.fl_str_mv oxidative damage
neurodegeneration
transgenic
knockout mice
topic oxidative damage
neurodegeneration
transgenic
knockout mice
description Accumulated evidence indicates that oxidative stress plays a role in neurodegenerative diseases, such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis. Here, we emphasize the results provided by the technology of genetically modified animals. Studies with transgenic and knockout mice have allowed great advances in the research of oxidative stress in general and in the central nervous system, and are pointing to potential targets for the development of new drugs and therapies to disrupt the cycle of events that lead to neuronal death. Thus, genetically modified animals are a valuable tool for the comprehension of human diseases, including neurodegenerative ones.
publishDate 2006
dc.date.none.fl_str_mv 2006-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600034
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600034
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422006000600034
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.29 n.6 2006
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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