Trachylobane and kaurane diterpenes from Croton floribundus spreng

Detalhes bibliográficos
Autor(a) principal: Uchôa,Paula Karina S.
Data de Publicação: 2013
Outros Autores: Silva Jr.,José Nunes da, Silveira,Edilberto Rocha, Lima,Mary Anne S., Braz-Filho,Raimundo, Costa-Lotufo,Letícia Veras, Araújo,Ana Jérsia, Moraes,Manoel Odorico de, Pessoa,Claudia do Ó
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000600006
Resumo: A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.
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spelling Trachylobane and kaurane diterpenes from Croton floribundus sprengditerpenesCroton floribundusEuphorbiaceaeA new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.Sociedade Brasileira de Química2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000600006Química Nova v.36 n.6 2013reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422013000600006info:eu-repo/semantics/openAccessUchôa,Paula Karina S.Silva Jr.,José Nunes daSilveira,Edilberto RochaLima,Mary Anne S.Braz-Filho,RaimundoCosta-Lotufo,Letícia VerasAraújo,Ana JérsiaMoraes,Manoel Odorico dePessoa,Claudia do Óeng2013-08-08T00:00:00Zoai:scielo:S0100-40422013000600006Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2013-08-08T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Trachylobane and kaurane diterpenes from Croton floribundus spreng
title Trachylobane and kaurane diterpenes from Croton floribundus spreng
spellingShingle Trachylobane and kaurane diterpenes from Croton floribundus spreng
Uchôa,Paula Karina S.
diterpenes
Croton floribundus
Euphorbiaceae
title_short Trachylobane and kaurane diterpenes from Croton floribundus spreng
title_full Trachylobane and kaurane diterpenes from Croton floribundus spreng
title_fullStr Trachylobane and kaurane diterpenes from Croton floribundus spreng
title_full_unstemmed Trachylobane and kaurane diterpenes from Croton floribundus spreng
title_sort Trachylobane and kaurane diterpenes from Croton floribundus spreng
author Uchôa,Paula Karina S.
author_facet Uchôa,Paula Karina S.
Silva Jr.,José Nunes da
Silveira,Edilberto Rocha
Lima,Mary Anne S.
Braz-Filho,Raimundo
Costa-Lotufo,Letícia Veras
Araújo,Ana Jérsia
Moraes,Manoel Odorico de
Pessoa,Claudia do Ó
author_role author
author2 Silva Jr.,José Nunes da
Silveira,Edilberto Rocha
Lima,Mary Anne S.
Braz-Filho,Raimundo
Costa-Lotufo,Letícia Veras
Araújo,Ana Jérsia
Moraes,Manoel Odorico de
Pessoa,Claudia do Ó
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Uchôa,Paula Karina S.
Silva Jr.,José Nunes da
Silveira,Edilberto Rocha
Lima,Mary Anne S.
Braz-Filho,Raimundo
Costa-Lotufo,Letícia Veras
Araújo,Ana Jérsia
Moraes,Manoel Odorico de
Pessoa,Claudia do Ó
dc.subject.por.fl_str_mv diterpenes
Croton floribundus
Euphorbiaceae
topic diterpenes
Croton floribundus
Euphorbiaceae
description A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000600006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000600006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422013000600006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.36 n.6 2013
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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