Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos

Detalhes bibliográficos
Autor(a) principal: Chaves,Andréa Rodrigues
Data de Publicação: 2008
Outros Autores: Queiroz,Maria Eugênia Costa
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037
Resumo: A novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extraction, whereby the compounds are extracted into a polymer coating, polydimethylsiloxane (PDMS), on a magnetic stirring rod. The extraction is controlled by the partitioning coefficient of drugs between the PDMS and sample matrix, and upon the sample-extraction medium phase ratio. The SBSE technique has been applied successfully, with high sensitivities, to biomedical analysis of volatiles and for semi-volatiles drugs from biological sample, including urine, plasma, and saliva. SBSE combined with in situ derivatization, drugs quite more polar (e.g. metabolites) also can be analyzed.
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spelling Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicosstir-bar sorptive extraction (SBSE)drugsbiological fluidsA novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extraction, whereby the compounds are extracted into a polymer coating, polydimethylsiloxane (PDMS), on a magnetic stirring rod. The extraction is controlled by the partitioning coefficient of drugs between the PDMS and sample matrix, and upon the sample-extraction medium phase ratio. The SBSE technique has been applied successfully, with high sensitivities, to biomedical analysis of volatiles and for semi-volatiles drugs from biological sample, including urine, plasma, and saliva. SBSE combined with in situ derivatization, drugs quite more polar (e.g. metabolites) also can be analyzed.Sociedade Brasileira de Química2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037Química Nova v.31 n.7 2008reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422008000700037info:eu-repo/semantics/openAccessChaves,Andréa RodriguesQueiroz,Maria Eugênia Costapor2008-12-09T00:00:00Zoai:scielo:S0100-40422008000700037Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2008-12-09T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
title Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
spellingShingle Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
Chaves,Andréa Rodrigues
stir-bar sorptive extraction (SBSE)
drugs
biological fluids
title_short Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
title_full Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
title_fullStr Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
title_full_unstemmed Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
title_sort Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos
author Chaves,Andréa Rodrigues
author_facet Chaves,Andréa Rodrigues
Queiroz,Maria Eugênia Costa
author_role author
author2 Queiroz,Maria Eugênia Costa
author2_role author
dc.contributor.author.fl_str_mv Chaves,Andréa Rodrigues
Queiroz,Maria Eugênia Costa
dc.subject.por.fl_str_mv stir-bar sorptive extraction (SBSE)
drugs
biological fluids
topic stir-bar sorptive extraction (SBSE)
drugs
biological fluids
description A novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extraction, whereby the compounds are extracted into a polymer coating, polydimethylsiloxane (PDMS), on a magnetic stirring rod. The extraction is controlled by the partitioning coefficient of drugs between the PDMS and sample matrix, and upon the sample-extraction medium phase ratio. The SBSE technique has been applied successfully, with high sensitivities, to biomedical analysis of volatiles and for semi-volatiles drugs from biological sample, including urine, plasma, and saliva. SBSE combined with in situ derivatization, drugs quite more polar (e.g. metabolites) also can be analyzed.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422008000700037
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.31 n.7 2008
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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