Development of dissolution method for benznidazole tablets

Detalhes bibliográficos
Autor(a) principal: Lima,Ádley Antonini Neves de
Data de Publicação: 2009
Outros Autores: Soares Sobrinho,José Lamartine, Silva,Jeckson Luiz da, Corrêa Júnior,Roberto Antônio Cavadinha, Lyra,Magaly Andreza Marques, Rolim Neto,Pedro José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000800034
Resumo: The aim of this work was the development of a dissolution method for benznidazole (BNZ) tablets. Three different types of dissolution media, two stirring speeds and apparatus 2 (paddle) were used. The accomplishment of the drug dissolution profiles was compared through the dissolution efficiency. The assay was performed by spectrophotometry at 324 nm. The better conditions were: sodium chloride\hydrochloride acid buffer pH 1.2 with stirring speed of 75 rpm, volume of 900 mL and paddle as apparatus. Ahead of the results it can be concluded that the method developed consists in an efficient alternative for assays of dissolution for benznidazole tablets.
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spelling Development of dissolution method for benznidazole tabletsdissolutionChagas diseasebenznidazoleThe aim of this work was the development of a dissolution method for benznidazole (BNZ) tablets. Three different types of dissolution media, two stirring speeds and apparatus 2 (paddle) were used. The accomplishment of the drug dissolution profiles was compared through the dissolution efficiency. The assay was performed by spectrophotometry at 324 nm. The better conditions were: sodium chloride\hydrochloride acid buffer pH 1.2 with stirring speed of 75 rpm, volume of 900 mL and paddle as apparatus. Ahead of the results it can be concluded that the method developed consists in an efficient alternative for assays of dissolution for benznidazole tablets.Sociedade Brasileira de Química2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000800034Química Nova v.32 n.8 2009reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422009000800034info:eu-repo/semantics/openAccessLima,Ádley Antonini Neves deSoares Sobrinho,José LamartineSilva,Jeckson Luiz daCorrêa Júnior,Roberto Antônio CavadinhaLyra,Magaly Andreza MarquesRolim Neto,Pedro Joséeng2009-12-03T00:00:00Zoai:scielo:S0100-40422009000800034Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2009-12-03T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development of dissolution method for benznidazole tablets
title Development of dissolution method for benznidazole tablets
spellingShingle Development of dissolution method for benznidazole tablets
Lima,Ádley Antonini Neves de
dissolution
Chagas disease
benznidazole
title_short Development of dissolution method for benznidazole tablets
title_full Development of dissolution method for benznidazole tablets
title_fullStr Development of dissolution method for benznidazole tablets
title_full_unstemmed Development of dissolution method for benznidazole tablets
title_sort Development of dissolution method for benznidazole tablets
author Lima,Ádley Antonini Neves de
author_facet Lima,Ádley Antonini Neves de
Soares Sobrinho,José Lamartine
Silva,Jeckson Luiz da
Corrêa Júnior,Roberto Antônio Cavadinha
Lyra,Magaly Andreza Marques
Rolim Neto,Pedro José
author_role author
author2 Soares Sobrinho,José Lamartine
Silva,Jeckson Luiz da
Corrêa Júnior,Roberto Antônio Cavadinha
Lyra,Magaly Andreza Marques
Rolim Neto,Pedro José
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lima,Ádley Antonini Neves de
Soares Sobrinho,José Lamartine
Silva,Jeckson Luiz da
Corrêa Júnior,Roberto Antônio Cavadinha
Lyra,Magaly Andreza Marques
Rolim Neto,Pedro José
dc.subject.por.fl_str_mv dissolution
Chagas disease
benznidazole
topic dissolution
Chagas disease
benznidazole
description The aim of this work was the development of a dissolution method for benznidazole (BNZ) tablets. Three different types of dissolution media, two stirring speeds and apparatus 2 (paddle) were used. The accomplishment of the drug dissolution profiles was compared through the dissolution efficiency. The assay was performed by spectrophotometry at 324 nm. The better conditions were: sodium chloride\hydrochloride acid buffer pH 1.2 with stirring speed of 75 rpm, volume of 900 mL and paddle as apparatus. Ahead of the results it can be concluded that the method developed consists in an efficient alternative for assays of dissolution for benznidazole tablets.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000800034
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000800034
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422009000800034
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.32 n.8 2009
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
_version_ 1750318109880745984

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