Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos

Detalhes bibliográficos
Autor(a) principal: Rodríguez,Vania
Data de Publicação: 2006
Outros Autores: Moura,Sidnei, Pinto,Ernani, Pereira,Claudio M. P., Braga,Rodolpho Campos
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600036
Resumo: Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamic and toxicological studies. Some strategies for the synthesis of anatoxin-a and analogous compounds are described herein, covering the period from 1996 to the present date. In this review, emphasis is given to the chemical and toxicological aspects of some variants of anatoxin-a, including homoanatoxin-a and anatoxin-a(s).
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spelling Aspectos toxicológicos e químicos da Anatoxina-a e seus análogosanatoxin-aalgaealkaloidsAnatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamic and toxicological studies. Some strategies for the synthesis of anatoxin-a and analogous compounds are described herein, covering the period from 1996 to the present date. In this review, emphasis is given to the chemical and toxicological aspects of some variants of anatoxin-a, including homoanatoxin-a and anatoxin-a(s).Sociedade Brasileira de Química2006-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600036Química Nova v.29 n.6 2006reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422006000600036info:eu-repo/semantics/openAccessRodríguez,VaniaMoura,SidneiPinto,ErnaniPereira,Claudio M. P.Braga,Rodolpho Campospor2011-09-06T00:00:00Zoai:scielo:S0100-40422006000600036Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2011-09-06T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
title Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
spellingShingle Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
Rodríguez,Vania
anatoxin-a
algae
alkaloids
title_short Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
title_full Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
title_fullStr Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
title_full_unstemmed Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
title_sort Aspectos toxicológicos e químicos da Anatoxina-a e seus análogos
author Rodríguez,Vania
author_facet Rodríguez,Vania
Moura,Sidnei
Pinto,Ernani
Pereira,Claudio M. P.
Braga,Rodolpho Campos
author_role author
author2 Moura,Sidnei
Pinto,Ernani
Pereira,Claudio M. P.
Braga,Rodolpho Campos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rodríguez,Vania
Moura,Sidnei
Pinto,Ernani
Pereira,Claudio M. P.
Braga,Rodolpho Campos
dc.subject.por.fl_str_mv anatoxin-a
algae
alkaloids
topic anatoxin-a
algae
alkaloids
description Anatoxin-a and its analogues are azabicyclic alkaloids that represent one of the most powerful nicotinic agonists known for the nicotinic acetylcholine receptor (nAChR). Because of this potent mechanism of action, anatoxin-a and its derivatives represent a target for the discovery of novel drugs. Their syntheses are useful for environmental monitoring and also for pharmacokinetic/pharmacodynamic and toxicological studies. Some strategies for the synthesis of anatoxin-a and analogous compounds are described herein, covering the period from 1996 to the present date. In this review, emphasis is given to the chemical and toxicological aspects of some variants of anatoxin-a, including homoanatoxin-a and anatoxin-a(s).
publishDate 2006
dc.date.none.fl_str_mv 2006-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600036
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000600036
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0100-40422006000600036
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.29 n.6 2006
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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