Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol

Detalhes bibliográficos
Autor(a) principal: Marini,Vanderléia G.
Data de Publicação: 2014
Outros Autores: Martelli,Silvia M., Zornio,Clarice F., Caon,Thiago, Simões,Cláudia M. O., Micke,Gustavo A., Oliveira,Marcone A. L. de, Machado,Vanderlei G., Soldi,Valdir
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000500014
Resumo: Biodegradable nanoparticles (NPs) have received considerable attention because of their possible use in the development of strategies for the topical delivery of oils and therapeutic drugs, particularly when drug penetration in dermis is desired. Zein is a prolamine and is a promising material for the design of drug delivery systems. In this study, NPs were prepared with zein and were used to encapsulate and release terpinen-4-ol, which is a therapeutic agent for the treatment of melanoma. The results show that the zein NPs are promising nanostructured systems for the prolonged delivery of T4OL with potential applications in anti-melanoma therapy.
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spelling Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-olzein nanoparticlesterpinen-4-olin vitro releaseBiodegradable nanoparticles (NPs) have received considerable attention because of their possible use in the development of strategies for the topical delivery of oils and therapeutic drugs, particularly when drug penetration in dermis is desired. Zein is a prolamine and is a promising material for the design of drug delivery systems. In this study, NPs were prepared with zein and were used to encapsulate and release terpinen-4-ol, which is a therapeutic agent for the treatment of melanoma. The results show that the zein NPs are promising nanostructured systems for the prolonged delivery of T4OL with potential applications in anti-melanoma therapy.Sociedade Brasileira de Química2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000500014Química Nova v.37 n.5 2014reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20140135info:eu-repo/semantics/openAccessMarini,Vanderléia G.Martelli,Silvia M.Zornio,Clarice F.Caon,ThiagoSimões,Cláudia M. O.Micke,Gustavo A.Oliveira,Marcone A. L. deMachado,Vanderlei G.Soldi,Valdireng2014-07-28T00:00:00Zoai:scielo:S0100-40422014000500014Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2014-07-28T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
title Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
spellingShingle Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
Marini,Vanderléia G.
zein nanoparticles
terpinen-4-ol
in vitro release
title_short Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
title_full Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
title_fullStr Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
title_full_unstemmed Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
title_sort Biodegradable nanoparticles obtained from zein as a drug delivery system for terpinen-4-ol
author Marini,Vanderléia G.
author_facet Marini,Vanderléia G.
Martelli,Silvia M.
Zornio,Clarice F.
Caon,Thiago
Simões,Cláudia M. O.
Micke,Gustavo A.
Oliveira,Marcone A. L. de
Machado,Vanderlei G.
Soldi,Valdir
author_role author
author2 Martelli,Silvia M.
Zornio,Clarice F.
Caon,Thiago
Simões,Cláudia M. O.
Micke,Gustavo A.
Oliveira,Marcone A. L. de
Machado,Vanderlei G.
Soldi,Valdir
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marini,Vanderléia G.
Martelli,Silvia M.
Zornio,Clarice F.
Caon,Thiago
Simões,Cláudia M. O.
Micke,Gustavo A.
Oliveira,Marcone A. L. de
Machado,Vanderlei G.
Soldi,Valdir
dc.subject.por.fl_str_mv zein nanoparticles
terpinen-4-ol
in vitro release
topic zein nanoparticles
terpinen-4-ol
in vitro release
description Biodegradable nanoparticles (NPs) have received considerable attention because of their possible use in the development of strategies for the topical delivery of oils and therapeutic drugs, particularly when drug penetration in dermis is desired. Zein is a prolamine and is a promising material for the design of drug delivery systems. In this study, NPs were prepared with zein and were used to encapsulate and release terpinen-4-ol, which is a therapeutic agent for the treatment of melanoma. The results show that the zein NPs are promising nanostructured systems for the prolonged delivery of T4OL with potential applications in anti-melanoma therapy.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000500014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0100-4042.20140135
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.37 n.5 2014
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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