Intestinal parasites infection: protective effect in rheumatoid arthritis?
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Reumatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461 |
Resumo: | Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper. |
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Intestinal parasites infection: protective effect in rheumatoid arthritis?Rheumatoid arthritisHelminth infectionsImmunomodulationAbstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper.Sociedade Brasileira de Reumatologia2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461Revista Brasileira de Reumatologia v.57 n.5 2017reponame:Revista Brasileira de Reumatologia (Online)instname:Sociedade Brasileira de Reumatologia (SBR)instacron:SBR10.1016/j.rbre.2016.06.004info:eu-repo/semantics/openAccessOliveira,Sandra Maximiano deGomides,Ana Paula MonteiroMota,Lícia Maria Henrique daLima,Caliandra Maria Bezerra LunaRocha,Francisco Airton Castroeng2017-11-21T00:00:00Zoai:scielo:S0482-50042017000500461Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0482-5004&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.php||sbre@terra.com.br1809-45700482-5004opendoar:2017-11-21T00:00Revista Brasileira de Reumatologia (Online) - Sociedade Brasileira de Reumatologia (SBR)false |
dc.title.none.fl_str_mv |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
title |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
spellingShingle |
Intestinal parasites infection: protective effect in rheumatoid arthritis? Oliveira,Sandra Maximiano de Rheumatoid arthritis Helminth infections Immunomodulation |
title_short |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
title_full |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
title_fullStr |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
title_full_unstemmed |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
title_sort |
Intestinal parasites infection: protective effect in rheumatoid arthritis? |
author |
Oliveira,Sandra Maximiano de |
author_facet |
Oliveira,Sandra Maximiano de Gomides,Ana Paula Monteiro Mota,Lícia Maria Henrique da Lima,Caliandra Maria Bezerra Luna Rocha,Francisco Airton Castro |
author_role |
author |
author2 |
Gomides,Ana Paula Monteiro Mota,Lícia Maria Henrique da Lima,Caliandra Maria Bezerra Luna Rocha,Francisco Airton Castro |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Sandra Maximiano de Gomides,Ana Paula Monteiro Mota,Lícia Maria Henrique da Lima,Caliandra Maria Bezerra Luna Rocha,Francisco Airton Castro |
dc.subject.por.fl_str_mv |
Rheumatoid arthritis Helminth infections Immunomodulation |
topic |
Rheumatoid arthritis Helminth infections Immunomodulation |
description |
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rbre.2016.06.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Reumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Reumatologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Reumatologia v.57 n.5 2017 reponame:Revista Brasileira de Reumatologia (Online) instname:Sociedade Brasileira de Reumatologia (SBR) instacron:SBR |
instname_str |
Sociedade Brasileira de Reumatologia (SBR) |
instacron_str |
SBR |
institution |
SBR |
reponame_str |
Revista Brasileira de Reumatologia (Online) |
collection |
Revista Brasileira de Reumatologia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Reumatologia (Online) - Sociedade Brasileira de Reumatologia (SBR) |
repository.mail.fl_str_mv |
||sbre@terra.com.br |
_version_ |
1750318051714138112 |