Intestinal parasites infection: protective effect in rheumatoid arthritis?

Detalhes bibliográficos
Autor(a) principal: Oliveira,Sandra Maximiano de
Data de Publicação: 2017
Outros Autores: Gomides,Ana Paula Monteiro, Mota,Lícia Maria Henrique da, Lima,Caliandra Maria Bezerra Luna, Rocha,Francisco Airton Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Reumatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461
Resumo: Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper.
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spelling Intestinal parasites infection: protective effect in rheumatoid arthritis?Rheumatoid arthritisHelminth infectionsImmunomodulationAbstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper.Sociedade Brasileira de Reumatologia2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461Revista Brasileira de Reumatologia v.57 n.5 2017reponame:Revista Brasileira de Reumatologia (Online)instname:Sociedade Brasileira de Reumatologia (SBR)instacron:SBR10.1016/j.rbre.2016.06.004info:eu-repo/semantics/openAccessOliveira,Sandra Maximiano deGomides,Ana Paula MonteiroMota,Lícia Maria Henrique daLima,Caliandra Maria Bezerra LunaRocha,Francisco Airton Castroeng2017-11-21T00:00:00Zoai:scielo:S0482-50042017000500461Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0482-5004&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.php||sbre@terra.com.br1809-45700482-5004opendoar:2017-11-21T00:00Revista Brasileira de Reumatologia (Online) - Sociedade Brasileira de Reumatologia (SBR)false
dc.title.none.fl_str_mv Intestinal parasites infection: protective effect in rheumatoid arthritis?
title Intestinal parasites infection: protective effect in rheumatoid arthritis?
spellingShingle Intestinal parasites infection: protective effect in rheumatoid arthritis?
Oliveira,Sandra Maximiano de
Rheumatoid arthritis
Helminth infections
Immunomodulation
title_short Intestinal parasites infection: protective effect in rheumatoid arthritis?
title_full Intestinal parasites infection: protective effect in rheumatoid arthritis?
title_fullStr Intestinal parasites infection: protective effect in rheumatoid arthritis?
title_full_unstemmed Intestinal parasites infection: protective effect in rheumatoid arthritis?
title_sort Intestinal parasites infection: protective effect in rheumatoid arthritis?
author Oliveira,Sandra Maximiano de
author_facet Oliveira,Sandra Maximiano de
Gomides,Ana Paula Monteiro
Mota,Lícia Maria Henrique da
Lima,Caliandra Maria Bezerra Luna
Rocha,Francisco Airton Castro
author_role author
author2 Gomides,Ana Paula Monteiro
Mota,Lícia Maria Henrique da
Lima,Caliandra Maria Bezerra Luna
Rocha,Francisco Airton Castro
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Sandra Maximiano de
Gomides,Ana Paula Monteiro
Mota,Lícia Maria Henrique da
Lima,Caliandra Maria Bezerra Luna
Rocha,Francisco Airton Castro
dc.subject.por.fl_str_mv Rheumatoid arthritis
Helminth infections
Immunomodulation
topic Rheumatoid arthritis
Helminth infections
Immunomodulation
description Abstract Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, with a progressive course, characterized by chronic synovitis that may evolve with deformities and functional disability, and whose early treatment minimizes joint damage. Its etiopathogenesis is not fully elucidated but comprises immunologic responses mediated by T helper cells (Th1). An apparent minor severity of RA in patients from regions with lower income could be associated with a higher prevalence of gut parasites, especially helminths. Strictly, a shift in the immune response toward the predominance of T helper cells (Th2), due to the chronic exposure to helminths, could modulate negatively the inflammation in RA patients, resulting in lower severity/joint injury. The interaction between the immunological responses of parasitic helminths in rheumatoid arthritis patients is the purpose of this paper.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042017000500461
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.rbre.2016.06.004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Reumatologia
publisher.none.fl_str_mv Sociedade Brasileira de Reumatologia
dc.source.none.fl_str_mv Revista Brasileira de Reumatologia v.57 n.5 2017
reponame:Revista Brasileira de Reumatologia (Online)
instname:Sociedade Brasileira de Reumatologia (SBR)
instacron:SBR
instname_str Sociedade Brasileira de Reumatologia (SBR)
instacron_str SBR
institution SBR
reponame_str Revista Brasileira de Reumatologia (Online)
collection Revista Brasileira de Reumatologia (Online)
repository.name.fl_str_mv Revista Brasileira de Reumatologia (Online) - Sociedade Brasileira de Reumatologia (SBR)
repository.mail.fl_str_mv ||sbre@terra.com.br
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